https://ijper-copy.vercel.app/ New articles published in Indian Journal of Pharmaceutical Education and Research. en Fri, 23 Oct 2026 00:00:00 GMT https://ijper-copy.vercel.app/article/61/1/1 https://ijper-copy.vercel.app/article/61/1/1 Fri, 23 Oct 2026 00:00:00 GMT Shravya Lakshmi Somashekar, Kiran Kumar Gubbi Basavaraju, Devegowda Vishakante Gowda Indian Journal of Pharmaceutical Education and Research Gastritis is a common gastrointestinal disorder with multiple etiologies, including infections, medication use, autoimmune conditions, and psychosocial stress. Among these, stress-induced gastritis remains unrecognized despite its increasing incidence in high-stress environments. This condition is characterized by inflammation of the gastric mucosa resulting from physiological or psychological stressors. The current review offers an in-depth examination of the complex pathogenesis of… https://ijper-copy.vercel.app/article/61/1/15 https://ijper-copy.vercel.app/article/61/1/15 Fri, 23 Oct 2026 00:00:00 GMT Yogesh Ashok Sonar, Hitendra Shaligram Mahajan Indian Journal of Pharmaceutical Education and Research Microneedle-based drug delivery has received considerable attention and is rapidly approaching commercialisation owing to the availability of different scalable techniques to yield various microneedles. Numerous materials such as metals, silicones, polymers, and carbohydrates have been employed to fabricate microneedles. Microneedles offer a range of benefits to patients, not only because of their minimally invasive and comfortable nature, but also because of their availability in various… https://ijper-copy.vercel.app/article/61/1/24 https://ijper-copy.vercel.app/article/61/1/24 Fri, 23 Oct 2026 00:00:00 GMT Sangeetha Saravanan, Anandharaj Govindaraj, Rajinikanth Baskaran, Gomathy Subramanian Indian Journal of Pharmaceutical Education and Research Cancer remains a significant global health challenge, with increasing incidence rates despite advancements in treatment modalities. Chemoprevention, utilising natural or synthetic agents to hinder, delay, or reverse carcinogenesis, has emerged as a promising approach to reduce cancer risk alongside conventional therapies. This review explores the roles of various natural compounds, including plant-derived phytochemicals such as curcumin, resveratrol, Epigallocatechin Gallate (EGCG), and… https://ijper-copy.vercel.app/article/61/1/33 https://ijper-copy.vercel.app/article/61/1/33 Fri, 23 Oct 2026 00:00:00 GMT Sanjana Katlaria, Yogita Tyagi Indian Journal of Pharmaceutical Education and Research Migraine is a complicated neurovascular condition that significantly impairs quality of life and productivity, affecting over one billion individuals worldwide. While conventional therapies such as NSAIDs, triptans, and ergot derivatives provide temporary relief, their effectiveness is sometimes limited by low brain penetration, delayed onset of action, and systemic side effects. Liposomes, which are nanoscale vesicles capable of encapsulating both hydrophilic and lipophilic drugs, have emerged… https://ijper-copy.vercel.app/article/61/1/43 https://ijper-copy.vercel.app/article/61/1/43 Fri, 23 Oct 2026 00:00:00 GMT Kirti Barkale, Gauri Khaladkar, Gayatri Kotwal, Umesh Laddha, Gangadhar Magar Indian Journal of Pharmaceutical Education and Research Background: Non-Alcoholic Fatty Liver Disease (NAFLD), Type 2 Diabetes Mellitus (T2DM), and depression are interlinked chronic conditions that share common pathophysiological mechanisms such as insulin resistance, chronic inflammation, and oxidative stress. Emerging evidence suggests that Vitamin D deficiency may represent a common underlying factor that contributes to the development and progression of these conditions. Objectives: This review aims to examine the multifaceted role of Vitamin D… https://ijper-copy.vercel.app/article/61/1/54 https://ijper-copy.vercel.app/article/61/1/54 Fri, 23 Oct 2026 00:00:00 GMT Pallavi Bolade Manjunatha, Gunavathi Honnashettihalli Dharmaraj, Prasad Bettadasathenhalli Verabhadrappa, Hemanth Prasad Konasuru Puttaraju, Sirivennala Murali Mohan, Abhishek Pete Nagaraj Indian Journal of Pharmaceutical Education and Research Cardiovascular Diseases (CVDs) are still a leading cause of morbidity and mortality worldwide, which has led to increased research in personalized approaches to therapy, new drug targets, and more understanding of comorbidities. The importance of the CYP2C19 polymorphisms and their role in the metabolism of the cardiovascular drug clopidogrel to establish whether there is an opportunity for precision medicine: genetic testing using PCR-based assays can identify patients with loss-of-function… https://ijper-copy.vercel.app/article/61/1/66 https://ijper-copy.vercel.app/article/61/1/66 Fri, 23 Oct 2026 00:00:00 GMT Patnam Nageswari, Karri Swathi Priya, Ketha Srilekhya, Yaso Deepika, Surya Neeraja Nagalla, Shashikala Metri, Mattakoyya Jhansi Rani, Bandaru Nagaraju, Jamal Bati Kuresa Indian Journal of Pharmaceutical Education and Research Alzheimer's disease, Parkinson's disease, multiple sclerosis, and autism spectrum disorders are only a few of the neurodegenerative and neuropsychiatric conditions that are significantly influenced by neuroinflammation. The gut microbiota produces Short-Chain Fatty Acids (SCFAs), mainly acetate, propionate, and butyrate, by fermentation of dietary fibers. These are among the new modulators of neuroinflammation, have attracted significant scientific interest. This review critically examines the… https://ijper-copy.vercel.app/article/61/1/77 https://ijper-copy.vercel.app/article/61/1/77 Fri, 23 Oct 2026 00:00:00 GMT Mohamed M A E L Salem, Mohammed A M Salih, Hanin M M Salem, Muhammad Shahid, Amjad Shahzad Indian Journal of Pharmaceutical Education and Research Objectives: This study evaluated the implementation of a Team-Based Learning modified TBL approach in Biotechnology and Chemistry modules at the University of Azad Jammu and Kashmir and explored its impact on students' academic performance and perceptions. Background: Traditional lecture-based methods in higher education have faced criticism for limited effectiveness in engaging students and fostering critical thinking. The modified TBL approaches have increasingly been adopted in science… https://ijper-copy.vercel.app/article/61/1/84 https://ijper-copy.vercel.app/article/61/1/84 Fri, 23 Oct 2026 00:00:00 GMT Vedanshu Malviya, Shrikant Pande Indian Journal of Pharmaceutical Education and Research Background: Repaglinide is an oral antidiabetic agent which has inadequate water solubility and is highly first-pass metabolized (poor bioavailability 50-60%), thus necessitating frequent administration. Solid Lipid Nanoparticles (SLNs) present a promising approach to improve the absorption of drugs and extend their release. Materials and Methods: Repaglinide-SLNs were prepared by incorporating hot melt emulsification-ultrasonication using glycerol behenate as lipid core, Poloxamer 188 as the… https://ijper-copy.vercel.app/article/61/1/100 https://ijper-copy.vercel.app/article/61/1/100 Fri, 23 Oct 2026 00:00:00 GMT Mohini Mondal, Biplab Debnath, Swarupananda Mukherjee, Tapan Kumar Shaw Indian Journal of Pharmaceutical Education and Research Aim: This study presents a dose reduction with sustained action and increased bioavailability. Atorvastatin (ATV) is the drug of choice for the management of hyperlipidemia, and the commonly available marketed product of ATV is tablets. ATV is a poorly water-soluble drug showing with a low oral bioavailability (approximately 12%). The first-pass metabolism of ATV is another cause of its low bioavailability. Nanoliposome of ATV increases bioavailability, hypothesizing the reduction of metabolism… https://ijper-copy.vercel.app/article/61/1/110 https://ijper-copy.vercel.app/article/61/1/110 Fri, 23 Oct 2026 00:00:00 GMT Anju Bala, Inderjeet Verma, Chander Parkash Dora, Km Saiphali, Kapil Kumar, Tarun Kapoor Indian Journal of Pharmaceutical Education and Research Objectives: The study aimed to fabricate and characterize Oral Dispersible Film (ODF) containing PLGA polymeric nanoparticles of Eletriptan Hydrobromide (EH). The ODF system is designed to circumvent pre-systemic metabolism of drug and thereby augment the issue of low oral bioavailability of EH. Materials and Methods: Polymeric nanoparticles were prepared by the nanoprecipitation method using PLGA (50:50) as the polymer and poloxamer 188 as the surfactant. A Box-Behnken Design was employed to… https://ijper-copy.vercel.app/article/61/1/127 https://ijper-copy.vercel.app/article/61/1/127 Fri, 23 Oct 2026 00:00:00 GMT Heng Li Indian Journal of Pharmaceutical Education and Research Background: Colorectal cancer is a substantial global health issue, requiring the advancement of innovative therapeutic strategies beyond traditional methods. Despite progress in treatment options, colorectal cancer continues to be the second most fatal cancer worldwide, with anticipated increases in incidence and mortality rates over the coming decades. Objectives: The present study explored the anticancer effects of ligustilide against colon cancer HT-29 cells using in vitro and in silico… https://ijper-copy.vercel.app/article/61/1/137 https://ijper-copy.vercel.app/article/61/1/137 Fri, 23 Oct 2026 00:00:00 GMT Wenfeng Shi, Yugang Li, Zhu Shi Indian Journal of Pharmaceutical Education and Research Background: Osteoarthritis is a degenerative joint condition defined by the destruction of cartilage, resulting in pain, stiffness, and impaired joint function. There is a growing need for safe and effective therapies that can address the underlying causes of osteoarthritis and slow its development. Objectives: This study assessed the efficacy of thymoquinone in ameliorating experimentally induced osteoarthritis in rats and investigated the mechanisms by which thymoquinone influences… https://ijper-copy.vercel.app/article/61/1/147 https://ijper-copy.vercel.app/article/61/1/147 Fri, 23 Oct 2026 00:00:00 GMT Zhenzhen Hao, Minhua Xiao, Yan Gao, Qian Wang, Jing Li, Li Guo Indian Journal of Pharmaceutical Education and Research Background: Chronic Kidney Disease (CKD), characterized by a progressive decrease in kidney function, has become a prominent health issue worldwide. The limitations of existing therapeutics for CKD underscore the pressing need for safe and effective alternative therapies that might target the underlying pathogenic pathways and inhibit disease progression. Objectives: In this work, we studied the nephroprotective effects of sarsasapogenin in adenine-induced CKD model in rats. Materials and… https://ijper-copy.vercel.app/article/61/1/156 https://ijper-copy.vercel.app/article/61/1/156 Fri, 23 Oct 2026 00:00:00 GMT Venkatesh Uppara, Bachu Venkata Ramana Indian Journal of Pharmaceutical Education and Research Introduction: Hyperglycaemia is a complicated condition that includes reduced production of insulin, resistance towards insulin, and oxidative imbalance. Current therapies often have limited efficacy and adverse effects, prompting interest in safer, multitarget alternatives. Traditional polyherbal formulations have been used for diabetes, yet their mechanisms remain underexplored. Objectives: This study evaluated the antidiabetic potential of a standardized Polyherbal Preparation (EPHP 1)… https://ijper-copy.vercel.app/article/61/1/169 https://ijper-copy.vercel.app/article/61/1/169 Fri, 23 Oct 2026 00:00:00 GMT Xinxiang Xu Indian Journal of Pharmaceutical Education and Research Background: Lung cancer is a pervasive global malignancy that stands as a foremost cause of cancer-induced fatalities, defined by its heightened intratumor heterogeneity and the intricate nature of its cellular pathology. It accounts for an estimated 25% of all global cancer-related fatalities, making it the primary cause of cancer deaths despite the development of clinical treatments. Objectives: The present work was designed to evaluate the anticancer mechanisms of senegenin against lung… https://ijper-copy.vercel.app/article/61/1/180 https://ijper-copy.vercel.app/article/61/1/180 Fri, 23 Oct 2026 00:00:00 GMT Lu Yan, Yiyang Li, Cuiyu Han, Rui Gao, Sining Xing, Jie Yang Indian Journal of Pharmaceutical Education and Research Background: Leukemia, a hematological malignancy resulting from impaired blood cell formation in the bone marrow, is a considerable global health challenge, inflicting major burdens on individuals and healthcare systems. Current therapeutic strategies for leukemia, while exhibiting efficacy in certain contexts, frequently encounter significant limitations such as severe adverse effects and the development of drug resistance. Objectives: The current work was committed to investigating the… https://ijper-copy.vercel.app/article/61/1/190 https://ijper-copy.vercel.app/article/61/1/190 Fri, 23 Oct 2026 00:00:00 GMT Suhasini Boddu, Karthikeyan Ramadoss, Kiranmai Mandava, Prakash Katakam Indian Journal of Pharmaceutical Education and Research Background: 3D printing holds great promise for the development of innovative, individualised approaches to the distribution of medicinal products. The use of 3D printing to create objects with antibiotics has many advantages, such as more precise drug content and better drug distribution. Aim: This study aimed to develop polyherbal antimicrobial discs using 3D printing technology. Materials and Methods: Using HPMC-K100M and PEG-400, plant extracts of Artemisia vulgaris, Hemionitis arifolia,… https://ijper-copy.vercel.app/article/61/1/200 https://ijper-copy.vercel.app/article/61/1/200 Fri, 23 Oct 2026 00:00:00 GMT Lin Zhang, Meilan Zhou, Amirah Albaqami, Omar Oraibi, Mohammed Somaili, May Mireani Indian Journal of Pharmaceutical Education and Research Background: Diabetic nephropathy is becoming an alarming concern globally as the percentage of patients is increasing day by day. Although the suffering rate was too high, the existing treatment was very limited and non-targeted. Objectives: To overcome this condition, the plant flavonoid Isorhamnetin (ISN) was used in this study to investigate its protective effect on hyperglycemia-mediated diabetic nephropathy. Materials and Methods: Cytotoxicity and nephroprotective potency of Isorhamnetin… https://ijper-copy.vercel.app/article/61/1/212 https://ijper-copy.vercel.app/article/61/1/212 Fri, 23 Oct 2026 00:00:00 GMT Shihan Fu Indian Journal of Pharmaceutical Education and Research Aim/Background: The growing need for novel methods of preparing nanoparticles is evident in recent scientific pursuits. Environmental concerns about the security of current production processes are growing along with interest in this subject. Current nanoparticle production processes are frequently costly and include the use of environmentally detrimental substances. This work investigates the production of Gold Nanoparticles (AuNPs) by using Ziziphus zizyphus leaf extract. This method provides… https://ijper-copy.vercel.app/article/61/1/222 https://ijper-copy.vercel.app/article/61/1/222 Fri, 23 Oct 2026 00:00:00 GMT Ahad Amer Alsaiari, Hanadi M Zbrmawi, Jawaher Amer Alsaiari, Mariam M Jaddah, Aisha Abdullah Alshanqiti, Amal Saeed Al Ayed, Hanan Salem Alghamdi Indian Journal of Pharmaceutical Education and Research Background: Breast cancer was the second most deadly cancer, especially in women. Recent data show that the incidence rate has been slowly rising over time and now it is becoming a global problem. This increasing problem shows how important it is to move away from traditional therapies and toward treatments that use bioactive compounds, which may be safer and more effective. The current study examines the antiproliferative effect of the steroidal alkaloid Conessine on the Human Breast… https://ijper-copy.vercel.app/article/61/1/231 https://ijper-copy.vercel.app/article/61/1/231 Fri, 23 Oct 2026 00:00:00 GMT Shuyun Ding, Li Li, Feiyun Jiang, Yifan Mao Indian Journal of Pharmaceutical Education and Research Objectives: To investigate the effect of baicalin on placental tissue injury in Preeclampsia (PE) rats and its possible mechanism. Materials and Methods: The caudal arterial blood pressure of Ed 1 5 and Ed 2 1 rats was detected. Bradford method was used to detect the 24 hr urinary protein content. The serum levels of Tumor Necrosis Factor-α (TNF-α), Interferon-γ (IFN-γ), Interleukin-4 (IL 4), Interleukin 10 (IL 10), Interleukin-33 (IL 33) and soluble growth Stimulating expression gene 2 protein… https://ijper-copy.vercel.app/article/61/1/240 https://ijper-copy.vercel.app/article/61/1/240 Fri, 23 Oct 2026 00:00:00 GMT Jingjian Zhang, Ying Cui, Ling Yang, Yan Lv Indian Journal of Pharmaceutical Education and Research Background: Lung Cancer (LC) is the foremost cause of worldwide cancer-related mortalities, principally, Non-Small Cell Lung Cancer (NSCLC). Pueraria lobata (PL) is a prominent traditional Chinese edible remedial plant that exerts anti-tumor and anti-inflammatory activity in many cancer cells. However, its anticancer mechanisms against NSCLC cells remain uncertain. Objectives: Hence, this anticancer study targeted the apoptotic activity and its cell signalling regulation of PL leaf extract (PL)… https://ijper-copy.vercel.app/article/61/1/248 https://ijper-copy.vercel.app/article/61/1/248 Fri, 23 Oct 2026 00:00:00 GMT Yanling Guo, Zhongting Pan Indian Journal of Pharmaceutical Education and Research Objectives: The liver is an essential organ that plays a vital role in detoxification and protection against harmful chemicals and toxicants. Nursing care for patients with liver disorders needs a comprehensive understanding of the disease, probable outcomes, and suitable nursing interventions. The present work was focused on assessing the hepatoprotective properties of Armepavine (ARM) against Acetaminophen (APAP)-induced liver damages in rats. Materials and Methods: A total to thirty male… https://ijper-copy.vercel.app/article/61/1/257 https://ijper-copy.vercel.app/article/61/1/257 Fri, 23 Oct 2026 00:00:00 GMT Shaoqiang Sun, Yingde Wang Indian Journal of Pharmaceutical Education and Research Aim: To determine the role of Proanthocyanidins (Pros) in mitigating Ulcerative Colitis (UC) in mice. Materials and Methods: A UC mouse model was constructed using dextran sulfate sodium induction in male adult Balb/c mice. Mice were randomly divided into Control, Model, Pro and Mesalazine groups. The pathological morphology of the colon was evaluated using the Disease Activity Index (DAI), colon appearance and length, IL-6, TNF-α and TGF-β levels and Hematoxylin and Eosin (HE) staining.… https://ijper-copy.vercel.app/article/61/1/266 https://ijper-copy.vercel.app/article/61/1/266 Fri, 23 Oct 2026 00:00:00 GMT Samrat Paul, Anuradha Moirangthem, Nilanjana Ghosh, Sohini Sen, Sanjib Ray, Piyali Basak, Anupam Basu Indian Journal of Pharmaceutical Education and Research Background: The increasing incidence of breast cancer remains a major global health challenge despite notable progress in diagnosis and therapy. Many patients progress to metastatic stages, where current treatments are not only costly but often less effective. This has emphasized the need to identify affordable alternative with anti-metastatic potential. Moringa oleifera, widely recognized for its cancer-preventative potential, was the focus of this study that explore its anti-metastatic… https://ijper-copy.vercel.app/article/61/1/274 https://ijper-copy.vercel.app/article/61/1/274 Fri, 23 Oct 2026 00:00:00 GMT Xuan Liu, Minhua Tan, Yanling Ren, Yani Wang Indian Journal of Pharmaceutical Education and Research Background: This study investigates the antidiabetic effects of Curcuma longa extract using in vitro enzyme assays, network pharmacology, and in silico molecular docking to elucidate its molecular mechanisms. Materials and Methods: From 133 Curcuma longa phytochemicals screened via TCMSP, 52 underwent ADMET and toxicity analysis using Protox-3, Superpred, and SwissTargetPrediction. Ethanol-based Soxhlet extraction was performed on the rhizome. Compounds were filtered by ADME/toxicity profiles,… https://ijper-copy.vercel.app/article/61/1/286 https://ijper-copy.vercel.app/article/61/1/286 Fri, 23 Oct 2026 00:00:00 GMT Hui Xu, Qiuming Zhou, Jinming Lu, Hao Zhang Indian Journal of Pharmaceutical Education and Research Background: Osteoarthritis (OA), a degenerative joint disorder, demands multi-target therapeutic strategies. Rhazya stricta, a traditional medicinal plant, was explored for its phytochemicals and their anti-OA potential. Objectives: To investigate Rhazya stricta's anti-OA mechanisms via integrated network pharmacology and experimental validation. Materials and Methods: Phytochemicals from IMPPAT and KNAPSACK databases (39 compounds) underwent ADME/toxicity screening (SwissADME, Molsoft,… https://ijper-copy.vercel.app/article/61/1/298 https://ijper-copy.vercel.app/article/61/1/298 Fri, 23 Oct 2026 00:00:00 GMT Lan Wang, Di Wang, Qingli Yao Indian Journal of Pharmaceutical Education and Research Background: Chronic Obstructive Pulmonary Disease (COPD) has emerged as a foremost cause of worldwide illness. Exposure to Cigarette Smoke (CS) contributes to Oxidative Stress (OS) and inflammation, which is a chief cause of COPD. Objectives: Bacoside A (BA) is a triterpenoid saponin extracted from the plant Bacopa monnieri (Brahmi), renowned as a potent nerve stimulant, exerting antioxidant, anti-inflammatory, and anticancer activities. Materials and Methods: Previously, it has been… https://ijper-copy.vercel.app/article/61/1/308 https://ijper-copy.vercel.app/article/61/1/308 Fri, 23 Oct 2026 00:00:00 GMT Shubhangi Sutar, Radhika Shinde, Sachin Mali, Rachana Bhimanwar, Sandeep Patil, Sopan Nangare Indian Journal of Pharmaceutical Education and Research Background: Diabetes is a major chronic health problem worldwide that has acquired significant attention from the scientific community. One approach to managing glucose synthesis and reducing the risk of diabetes is through the inhibition of specific enzymes. Interestingly, heterocyclic compounds have been shown to effectively inhibit key enzymes involved in glucose metabolism, making them promising candidates for diabetes treatment. Materials and Methods: In this study, we aimed to dock the…