Volume 60, Issue 4

Original Article(continued)

1. Neuroprotective Effect of Stemona tuberose Leaf Extract on MCAO/R-Induced Rats via P13K/Akt Signaling Pathway

   Changqing Li, Junpeng Meng

   pp. 1555-1563 · DOI: 10.5530/ijper.20261510 · 2026

   Background: Ischemic Stroke (IS) is a serious illness with great fatality and disability globally. The pathophysiological causes of IS are oxidative stress, apoptosis and neuroinflammation. Objectives: Cerebral Ischemia/…

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2. Analysis of the Inhibitory Effect of Dihydroartemisinin on Inflammatory Responses in Mice with Neuropathic Pain Induced by the Japanese Encephalitis Virus NS1

   Hui Wang, Jie Xia

   pp. 1564-1571 · DOI: 10.5530/ijper.20261715 · 2026

   Objectives: To elucidate the underlying mechanism through which Dihydroartemisinin (DHA) exerts its influence on mice with Neuropathic Pain (NP) induced by the NS1 protein of the Japanese Encephalitis Virus (JEV). Materi…

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3. Polysaccharides from Phellinus linteus (Phps) Protect against Doxorubicin-Induced Myocardial Inflammatory Injury in Mice through PI3K/Akt/mTOR Signaling Pathway

   Xiaoyu Ren, Jinfeng Wang, Yuan Zhou, Lili Jiang, Fei Liu, Qingxian Mei

   pp. 1572-1578 · DOI: 10.5530/ijper.20261835 · 2026

   Aim/Background: To study the improvement effect of Phellinus linteus polysaccharides (Phps) on doxorubicin-induced myocarditis injury in mice. Materials and Methods: The mice were randomly divided into 5 groups, namely b…

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4. Hepatoprotective Role of Melaleuca leucadendra and Cassia surattensis Extracts against Isoniazid and Rifampicin-Induced Hepatotoxicity in Swiss Albino Mice

   Annu Bhati, Avijit Mazumder, Priyanka Bansal, Motamarri Venkata Naga Lalitha Chaitanya

   pp. 1579-1586 · DOI: 10.5530/ijper.20262755 · 2026

   Background: Liver disorders arising from various causes, including infections, toxins, and certain medications, remain a significant global health challenge. Ongoing research focuses on the development of novel drug comp…

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5. Tricin Ameliorates Renal Fibrosis and Inhibits the Progression of Chronic Kidney Disease in Adenine-Induced Rats

   Yang Xu, Jianmin Zhang, Yapu Zhang, Yanli Gou, Qian Wang, Xuezhong Li, Kai Li

   pp. 1587-1595 · DOI: 10.5530/ijper.20263001 · 2026

   Background: Renal fibrosis, a defining feature of Chronic Kidney Disease (CKD) development, is marked by the over deposition of extracellular matrix proteins, resulting in structural and functional impairment of the kidn…

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6. Tanshinone ⅡA Ameliorates Chronic Unpredictable Mild Stress Induced Depression-Like Behaviors: Integrating Network Pharmacology and Molecular Mechanism Evaluation

   Qun Li, Yuancheng Jin, Yuhua Wu, Menglu Zhu, Saiwei Wu, Guoqing Zhang, Zhujin Song

   pp. 1596-1605 · DOI: 10.5530/ijper.20260395 · 2026

   Background: Depression is a commonly occurring mental disease and many active ingredients of herbs have been proven to effectively alleviate depression. Objectives: To investigate the effects of Tanshinone IIA (Tan IIA) …

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7. Effect of Pomiferin against Cyclophosphamide-Induced Mice by Immunomodulatory Effects and Involvement of the Inflammatory Cytokine Pathway

   Abdulkarim S. Binshaya, Khalid Alshaghdali

   pp. 1606-1617 · DOI: 10.5530/ijper.20261291 · 2026

   Background: Cyclophosphamide (Cy) is widely used in oncology and immunology for treating cancers and severe autoimmune diseases. However, its clinical utility is limited by adverse effects such as immunosuppression, hema…

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8. Metformin Affects Endometrial Carcinoma Cell Proliferation and Apoptosis by Regulating the Prognostic Marker S100a2 Expression

   Yang Liu, Boer Deng, Dan Luo, Jianjun Zhang, Weimin Kong

   pp. 1618-1623 · DOI: 10.5530/ijper.20260473 · 2026

   Background: To investigate the effects of metformin on the proliferation and apoptosis of human endometrial carcinoma cells, along with elucidating the potential underlying mechanisms, we conducted a study wherein the ca…

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9. Transferulic Acid Suppresses TNF α-induced β-Catenin Activation and Epithelial-Mesenchymal Transition in A549 Lung Cancer Cells

   Abdulmajeed M. Jali, Ali Hanbashi, Hamad Al Shahi, Faroq Kamli, Khalid Zoghebi

   pp. 1624-1635 · DOI: 10.5530/ijper.20264716 · 2026

   Background and Objectives: Lung cancer is a prevalent malignancy characterized by a high propensity for metastasis and is a rising contributor to mortality. The prognosis and treatment strategies have become challenging …

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10. Antipyretic Effect of Geniposide in Dry Yeast-Induced Pyrexia Rats via Intervening the Compositions of Gut Microbiota

    Xiao-lin Li, Sheng-fu Chen, Tian-long Liu, Ren-jie Wang, Rong Wang, Mao-Xing Li

    pp. 1636-1645 · DOI: 10.5530/ijper.20260479 · 2026

    Aim: Geniposide is the main active ingredient in Gardenia jasminoides Ellis, but its antipyretic mechanism is still unclear. Materials and Methods: To study the change of the gut microbiota in febrile rats with dry yeast…

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11. Glycyrrhizin Modulates the Inflammatory Response Induced by Ev71 Infection by Targeting the NF-κB pathway

    Qian Li, Yuechuan Zhang, Tianjiao Wang, Jiamei Wu

    pp. 1646-1655 · DOI: 10.5530/ijper.20261024 · 2026

    Background: Previous research has demonstrated that glycyrrhizin exhibits antioxidant, anti-inflammatory and antiapoptotic characteristics. In this study, RD cells were infected with Enterovirus 71 (EV71) and a cell mode…

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12. Chemical Characterization and Biological Potential of Simarouba glauca Leaf Extract: GC-MS, In vitro, and Molecular Docking Studies

    Padmapriya Sundaram, Selvi Sellappan, Mohammed Saleh Al Aboody, Wardah A. Alhoqail, Suresh Mickymaray, Kaviya Suresh

    pp. 1656-1669 · DOI: 10.5530/ijper.20264744 · 2026

    Background: Medicinal plants remain an important source of therapeutic agents due to their rich phytochemical composition and broad pharmacological activities. Simarouba glauca is a traditionally used medicinal plant; ho…

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13. Nano-Enabled Stem Cell Therapy Ameliorates Premature Ovarian Failure in Rats via Hormonal and Follicular Regeneration

    Qiangdong Zou, Yan Wang

    pp. 1670-1680 · DOI: 10.5530/ijper.20261329 · 2026

    Background: Premature ovarian failure (POF), clinically referred to as primary ovarian insufficiency (POI), represents a loss of ovarian function occurring before the age of 40 and remains a major cause of infertility in…

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14. Anti-Proliferative and Anti-Metastatic Effects of Conessine in Human Osteosarcoma Cells: In vitro and in silico Evidence Targeting MMP2 and MMP9

    Hafiz A. Makeen, Mohammad Albratty

    pp. 1681-1695 · DOI: 10.5530/ijper.20264949 · 2026

    Background: Osteosarcoma is a predominant bone cancer characterised by increased metastatic potential, rapid proliferation, and insufficient clinical prognosis, making it the leading cause of cancer-related morbidity. Fi…

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15. Neuroprotective Effects of Tephrosin on Aluminium Chloride-induced Oxidative Stress Mediated Neuroinflammation in Rat Model of Alzheimer's Disease

    Hongxing Xue, Weijuan Nan, Qiang Li

    pp. 1696-1705 · DOI: 10.5530/ijper.20262570 · 2026

    Aim/Background: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder with limited therapeutic options. Tephrosin (TP), a natural rotenoid, exhibits antioxidant and anti-inflammatory properties. This study…

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16. Anticancer Potential of Didymin by Inducing Apoptosis in Thyroid Cancer TPC-1 Cells

    Hongli Yang, Qian Sun, Zhi Hao, Nana Li, Wei Liu, Fanjia Zeng, Dandan Liu, Zhibin Jiang

    pp. 1706-1712 · DOI: 10.5530/ijper.20263131 · 2026

    Background: Thyroid cancer, a tumor arising from the thyroid gland, impacts a considerable portion of the population, with incidence rates exhibiting an upward trend globally. The mortality rates for thyroid cancer are r…

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17. Characteristics of Patients with Familial Hypercholesterolemia and Acute Coronary Syndrome Prescribed PCSK9 Inhibitors

    Samar Zuhair Alshawwa, Lama AlRebdi, Nouf AlMasri, Mayada AlSuwaid, Amal Alnajjar, Reem Bahmaid, Faisal AlQarni, Khaled AlMatrafi, Sadaf Jamal Glani

    pp. 1713-1719 · DOI: 10.5530/ijper.20261849 · 2026

    Background: Patients with Familial Hypercholesterolemia (FH) or statin intolerance are significantly increasing. Therefore, a novel class of lipid-lowering drugs called Proprotein Convertase Subtilisin Kexin type 9 (PCSK…

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18. Nephroprotective effect of Dichrostachys cinerea Bark Extract against Streptozotocin Induced Diabetic Nephropathy Via Alteration of Oxidative Stress and Inflammation

    Kavitha Kandasamy, Zain Alabden Ghanim Ahmed Ahmed, Zead Helmi Abudayeh, Samer Hasan Hussein-Al-Ali, Shilpa Perumal Narasimhamoorthi, Palanisamy Arulselvan, Karunakaran Saravanan, Subbarayan Sarathbabu

    pp. 1720-1729 · DOI: 10.5530/ijper.20264263 · 2026

    Introduction: The primary trigger of End-Stage Renal Disease (ESRD) in several affluent nations, including the US, is diabetic nephropathy. Objectives: Diabetic nephropathy is a microvascular consequence that can occur i…

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19. Evaluation of the Protective Efficacy of Nigella sativa Oil with Some Hematological Parameters and ANAE Positive Lymphocyte Ratio in Bisphenol A Toxicity

    Mehmet Özsan, İlknur Ündağ, Nurcan Dönmez, Elif Aydın, Hasan Hüseyin Dönmez

    pp. 1730-1735 · DOI: 10.5530/ijper.20263488 · 2026

    Background and Aim: Bisphenol A (BPA) est chemicum endocrinum perturbans, late in variis productis consumptoriis adhibitum, quod per systemata endocrinum et immunologicum nocet valetudini. Huius studii propositum erat ex…

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20. A Stability Indicating RP-HPLC Method for Estimation of Favipiravir in Tablets

    Hemlata Manohar Nimje, Smita Pawar, Amol Kale, Trushal Chorage

    pp. 1736-1744 · DOI: 10.5530/ijper.20260817 · 2026

    Objectives: The focus of this research work was to develop an accurate and validated RP-HPLC technique for analysing Favipiravir (FAVI) drug and interpreting related degradants in drug and its formulation. Materials and …

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