In Press
Peer-reviewed and accepted articles published online ahead of their issue. Each is citable by its DOI and moves to its volume and issue once paginated.
In this issue
1–20 of 64Original Article
Xueyi Chen, Xueting Lin, Lingchen Liao, Yuzhou Pang, Gang Fang, Zhiyong Cao
pp. · DOI: 10.5530/ijper.20271757 · 2026
Background: This study aims to identify small alkaloid molecules that inhibit lysosomal acidification and explore their anti-tumor mechanisms. Vacuolar adenosine triphosphatase (v-ATPase) regulates lysosomal acidificatio…
Cui Changqiang, Zha Li, Ren Tailiang, Lin Xiaofei
pp. · DOI: 10.5530/ijper.20272027 · 2026
Background: Ovalbumin (OVA)-induced asthma in young rats is a widely used model to investigate airway inflammation and related molecular pathways. This study evaluated the therapeutic effects of LT on OVA-induced asthma …
Jianguo Hu, Hongxia Guo, Chuang Wang, Yun Chen
pp. · DOI: 10.5530/ijper.20272119 · 2026
Background/Objectives: Components potentially inducing tumor cell apoptosis were isolated from Gloydius brevicaudus venom, and their apoptotic mechanisms were investigated. Materials and Methods: The lyophilized venom wa…
Yuling Wang, Yan Long, Fengjuan Lyu, Huimin Cao, Chenggang Zhang
pp. · DOI: 10.5530/ijper.20262121 · 2026
Objectives: Cerebral ischemia is one cardio-cerebrovascular disease with the highest incidence, which will result in irreversible damage to brain function and even death. Rhizoma chuanxiong is a common Chinese medicine, …
Yang Xu, Yan Wang, Yuchao Mao, Yingli Ma
pp. · DOI: 10.5530/ijper.20272532 · 2026
Background: Liver cancer remains a leading cause of cancer-related deaths worldwide. Traditional Chinese Medicine (TCM), including Salvia miltiorrhiza (Danshen), has demonstrated potential anticancer properties. This stu…
Xiuxiu Zhao, Xueju Wang, Tianxiu Zhao
pp. · DOI: 10.5530/ijper.20262558 · 2026
Objectives: Ferroptosis, an iron-dependent cell death pathway driven by lipid peroxidation, exacerbates alveolar epithelial damage in pneumonia. As a glutathione precursor, N-Acetylcysteine (NAC) may modulate this proces…
Fangfang Sun, Juan Li
pp. · DOI: 10.5530/ijper.20262566 · 2026
Background: Myocardial Infarction (MI), or heart attack, is a severe complication resulting from a sudden and prolonged interruption of blood flow to a portion of the myocardium, causing cellular ischemia and subsequent …
Tingyu Min, Songjun Li, Xibin Zhang
pp. · DOI: 10.5530/ijper.20262572 · 2026
Background: Osteoporosis is a severe bone disease that has few effective treatment options and major side effects. Dipsacus inermis, a conventional medicinal plant, demonstrates potential via multi-target regulation of i…
Wentao Yao, Zhen Yan
pp. · DOI: 10.5530/ijper.20273030 · 2026
Background: Ischemic stroke is a major cause of long-lasting disability and even mortality globally, driven by the sudden blockage of cerebral blood flow and the subsequent pathophysiological events that ultimately lead …
Tihua Zhang, Danni Wang, Xin He
pp. · DOI: 10.5530/ijper.20251228 · 2026
Aim: This study aimed to investigate the renoprotective effects of menthone on Streptozotocin (STZ)-induced Diabetic Nephropathy (DN) in rats. Materials and Methods: The animals were divided into five groups. Each group …
Xiaoyun Zhang, Xinlong Xi, Wenming Bian, Jia Zhao, Qiang Liu
pp. · DOI: 10.5530/ijper.20261484 · 2026
Background: Myocardial Ischemia-Reperfusion Damage (MI/RI) has been identified as a major risk factor for cardiovascular disease. Reducing oxidative stress, inflammation, and apoptosis has emerged as a key therapeutic st…
Xiaoli Li, Zhirong Dai, Huimin Li, Bing Li
pp. · DOI: 10.5530/ijper.20273933 · 2026
Objectives: This study aimed to assess the effects of leuprorelin acetate combined with reverse addition therapy on the sex hormone levels in patients with ovarian endometriosis cyst. Materials and Methods: A total of 91…
Zhongjiang Niu, Fei Xiao, Alok S Tripathi
pp. · DOI: 10.5530/ijper.20264508 · 2026
Background: Diabetic Neuropathy (DN) is a common and debilitating complication of diabetes, characterized by neuronal dysfunction driven partly by oxidative stress, inflammation, and Advanced Glycation End Product (AGE)-…
Rashed M Almuqbil, Bandar Aldhubiab, Ahmed K K Mueen, Chaman Sab
pp. · DOI: 10.5530/ijper.20260025 · 2026
Objectives: Artificial Intelligence (AI) methods are increasingly applied to natural-product chemistry and drug discovery, but the resulting literature has grown rapidly and unevenly across subthemes. This study maps the…
Priya Palanisamy, Allimalarkodi Shanmugham, Venkatesh Aditiyaa Narayana, Sambath Kumar Ramanadhan
pp. · DOI: 10.5530/ijper.20270038 · 2026
Objectives: The objective of the study was to design, optimize, and evaluate dual drug-loaded itraconazole and quercetin PCL/PVP nanofibers for sustained localized delivery in the post-surgical management of skin cancers…
Venkatesh Aditiyaa Narayanaa, Vanitha Sureshkumar, Priya Palanisamy, Sambathkumar Ramanadhan
pp. · DOI: 10.5530/ijper.20270039 · 2026
Objectives: The objective of this study was to develop, optimize, and evaluate a dapsone-loaded transferosomal gel for enhanced topical delivery in acne vulgaris using a Box-Behnken Design (BBD). Acne vulgaris is an infl…
Paari Ellappan, Neelakandan Mani, Rajasekaran Duraisamy, Pari Leelavinothan
pp. · DOI: 10.5530/ijper.20270064 · 2026
Background: Dyslipidaemia, abnormal lipid metabolism and hepatic steatosis are common in patients with Diabetes Mellitus (DM) and contribute to the development of cardiovascular and metabolic complications. Valencene is …
Shruti Sanjay Salunkhe, Amit Suryakant Tapkir, Sneha Nandkumar Rashinkar, Pravin Digamber Choudhari, Ashok Bhau Pathak, Sandip Murlidhar Bhagat
pp. · DOI: 10.5530/ijper.20270087 · 2026
Background: The quality, safety, and regulatory compliance of rivaroxaban, an oral anticoagulant that is often prescribed. According to International Council for Harmonization (ICH) recommendations, impurity profiling, t…
Vishin Ashish Patil, Ashwin Jagannath Mali
pp. · DOI: 10.5530/ijper.20270147 · 2026
Background: Eriocitrin is a citrus flavonone, and has potential as a phytopharmaceutical compound. A robust and reliable analytical method is required for its routine quality control and quantification. Objectives: To es…
Aveek Datta, Subhasis Maity, Miltu Kumar Ghosh, Kuntal Hazra
pp. · DOI: 10.5530/ijper.20270150 · 2026
Background: Remogliflozin Etabonate (RE), a novel antidiabetic drug, suffers from poor aqueous solubility, which limits its oral bioavailability. This study aimed to develop and compare Solid Dispersion (SD) formulations…