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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Bronchoprotective, Bronchodilatory and Anti-Inflammatory Activity of Ethanolic Extract from Woodfordia fruticosa (Kurz.) Flowers

1, 1, 1, 2, 1

  1. 1Sharad Pawar College of Pharmacy, Wanadongari, Hingna Road, Nagpur-441 110 (M. S.), India.
  2. 2aNanded Pharmacy College, Shyam Nagar Nanded - 431605, (M.S).
  3. 3J. L. Chaturvedi College of Pharmacy, Electronic Zone, M. I. D. C. Hingna Road, Nagpur-440 016 (M. S.), India.

CORRESPONDENCE

M H Ghante

Sharad Pawar College of Pharmacy, Wanadongari, Hingna Road, Nagpur-441 110 (M. S.), India

am_mahavir@rediffmail.com

Received: 03-03-2011; Accepted: 27-12-2011.

Volume 46, Issue 2 · pp. 168-173 · 2012 · DOI:

ABSTRACT

The present investigation was aimed to investigate the bronchoprotective, bronchodilatory and anti-inflammatory effect of ethanol extract of Woodfordia fruticosa dried flower (WF-EE). WF-EE exhibited significant and dose dependent bronchoprotective, bronchodilatory and antiinflammatory effect. WF-EE at 200 mg/kg prolonged the latent period and exhibited protection against experimental asthma induced by the combination of histamine and acetylcholine aerosol in guinea pigs. WF-EE (1 mg/ml) exhibited 100 % bronchodilation (complete bronchorelaxation) at concentrations 1.6 and 3.2 mg against acetylcholine and histamine induced contraction respectively. Administration of extract (100 or 200 mg/kg, p.o.) to rats showed significant inhibition of carrageenan as well as egg albumin induced paw edema. The antiinflammatory effect of extract at 200 mg/kg was comparable to standard drug indomethacin (10 mg/kg, p.o.). Moreover, WF-EE has not shown any toxicity symptoms and mortality up to 2000 mg/kg, p.o. in rats, when evaluated for the acute toxicity study of WF-EE as per OECD guidelines. These results suggest the anti-asthmatic (bronchoprotective as well as bronchodilatory) and anti-inflammatory potential of WF-EE along with safety margin for oral administration.

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    Ghante, M., Bhusari, K., Duragkar, N., Jain, N., & Warokar, A. (2012). Bronchoprotective, Bronchodilatory and Anti-Inflammatory Activity of Ethanolic Extract from Woodfordia fruticosa (Kurz.) Flowers. Indian Journal of Pharmaceutical Education and Research, 46(2), 168-173.

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    © 2012 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0