Formulation and In-vitro Evaluation of Zidovudine-Lamivudine Nanoparticles
1, 1, 1
- 1Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India - 641004.
CORRESPONDENCE
V.Sankar
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India - 641004
Received: 26-07-2010; Accepted: 19-01-2012.
Volume 46, Issue 2 · pp. 192-196 · 2012 · DOI:
ABSTRACT
Human Immunodeficiency Virus infection and Acquired Immune Deficiency Syndrome commonly referred to as HIV/AIDS which have emerged as being the most serious and challenging public health problems in the world. Zidovudine-Lamivudine nanoparticles were prepared by emulsion polymerization in a continuous aqueous phase with different polymers poly(lactic-co-glycolic acid) PLGA (50:50), Poly(lactic acid) PLA, Poly (methyl methacrylate) PMMA, Methylmethacrylate-Sulfopropylmethacrylate (MMA-SPM). The particle size and the surface morphology results revealed that PLGA nanoparticles (NPs) were smooth spherical with a size ranging from 58-224 nm. The drug content in lyophilized PLGA NPs was found to be 51.67% (Zidovudine) 58.33% (Lamivudine) and no drug loss was found after storage for 1 month at room temperature. In vitro release studies revealed that the rate of drug release from PLGA NPs was 95.38% in 10 h with zidovudine, and 97.37% in 10 h with lamivudine which was slower when compared to MMA-SPM, PLA and PMMA NPs. The rate of drug release from MMA-SPM NPs was 64.33% in 10 h with zidovudine and 95.43% in 10 h with lamivudine. Acute toxicity studies in mice revealed that the dose administered does not induce mortality in test animal.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Sankar, V., Keerthi, L. M., & Parmar, N. (2012). Formulation and In-vitro Evaluation of Zidovudine-Lamivudine Nanoparticles. Indian Journal of Pharmaceutical Education and Research, 46(2), 192-196.
Copyright and licence
© 2012 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0