Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones
1, 1, 1, 1
- 1Department of pharmaceutical chemistry, JKK Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam - 638 183 Tamilnadu, India.
CORRESPONDENCE
B. Jayalakshmi
Asst. Prof. Department of Pharmaceutical Chemistry, JKK Munirajah Medical Research Foundation College of Pharmacy, Komarapalayam - 638 183, Tamilnadu, India E-mail : bjayavasan@gmail.com
Received: 03-05-2011; Accepted: 17-12-2011.
Volume 46, Issue 3 · pp. 206-210 · 2012 · DOI:
ABSTRACT
New 4-aryl substituted quinazolin-2-thiones were synthesized and confirmed by spectral studies like IR and NMR. Then screened for antimicrobial, analgesic, anti-inflammatory and CNS depressant activities. All the derivatives were showing the pharmacological activity mainly due to the presence of basic nucleus, quinazolin-2-thione and was modified with various substituents at 4th position with different aryl substituents. Among all the substituents, the halogen substituted compounds are comparatively more active.
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Aslak, C., Jayalakshmi, B., Balasubramaniam, A., & Senthilkumar, N. (2012). Synthesis and Pharmacological Evaluation of New 4-Aryl-3,4,5,6,7,8- hexahydroquinazolin-2(1H)-thiones. Indian Journal of Pharmaceutical Education and Research, 46(3), 206-210.
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