Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

In Silico Antigenicity Screening of Moringa Coagulant

1, 1, 1, 2, 3

  1. 1Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India.
  2. 2Pharmacy Group, Birla Institute of Technology and Science, Pilani, Rajasthan.
  3. 3Department of Bioinformatics and Microbiology, Shivaji University, Kolhapur- 416013, Maharashtra, India.

CORRESPONDENCE

Namdeo Jadhav

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, Maharashtra, India.

nrjadhav18@rediffmail.com

Received: 03-05-2012; Accepted: 29-11-2012.

Volume 47, Issue 2 · pp. 129-134 · 2013 · DOI:

ABSTRACT

Moringa coagulant (MC) obtained from the seeds of plant moringa oleifera (family- Moringaceae) has been substantially investigated for water purification, but, scarcely pharmaceutical applications. Recent investigations state its utility in dissolution enhancement of poorly soluble drugs, amorphous state stabilization and extended drug release. To broaden the applications of MC as a pharmaceutical excipient, need has been felt to test its antigenicity owing to its proteinic nature. In silico antigenicity screening has been carried out to enable its use in formulation of both parenteral and oral dosage form. Virtual screening carried out using online servers (ProtScale Analysis, BcePred, ABCPred, HLA-DR4Pred) predicted the probable antigenic epitopes of MC using hydrophobicity, hydrophilicity, exposed surface, secondary structure, antigenic propensity scale etc. Using these servers, the most probable antigenic regions in MC were observed to be 2-10, 29-34 and 47-53. The studies demonstrate that, MC may not pose difficulty in formulation of nonparenteral dosage forms, but, if intended for parenteral delivery, its antigenic domain needs to be exhaustively investigated

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Jadhav, N., Bhawale, B., Bhende, S., Patil, S., & Sonawane, K. (2013). In Silico Antigenicity Screening of Moringa Coagulant. Indian Journal of Pharmaceutical Education and Research, 47(2), 129-134.

    Copyright and licence

    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0