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Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants

1, 1, 2

  1. 1A. R. College of Pharmacy and G. H. Patel Institute of Pharmacy, PO Box No.19 Motabazar, Vallabh Vidyanagar-388120, Anand, Gujarat, India.
  2. 2Sanofi Aventis Pharmaceuticals Ltd. Ankleshwar, Gujarat, India.

CORRESPONDENCE

Narendra P. Chotai, A. R.

College of Pharmacy and G. H. Patel Institute of Pharmacy, PO Box No.19 Motabazar, Vallabh Vidyanagar-388120, Anand, Gujarat, India.

pharmacist_chotai2002@yahoo.co.in

Volume 47, Issue 3 · pp. 49-55 · 2013 · DOI: 10.5530/ijper.47.3.8

ABSTRACT

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. The aim of the present investigation was to prepare solid dispersion (SD) of OSH using superdisintegrants as carrier and formulate it as fast dissolving tablets (FDTs) with an objective to improve solubility and enhance dissolution of drug. SD of drug using superdisintegrants like croscarmellose sodium (CCS), crospovidone (CP), sodium starch glycolate (SSG), and low substituted hydroxy propyl cellulose (L-HPC) respectively as carriers was prepared by solvent evaporation method. The prepared SD formulations were characterized by equilibrium solubility, fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC) and dissolution study. FTIR spectra revealed no chemical interaction between the drug and superdisintegrants. XRPD and DSC data indicated that OSH was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispersions. Various batches of FDTs (F1-F10) were prepared using selected SD formulation of drug and carrier (1:3 ratio) and evaluated for various physical parameters and drug release study. The batch containing SD formulation in CP (F3) showed fastest disintegration (3.22s), least wetting time (10.5s) and higher dissolution (97.98% drug release in 30 min). In conclusion, FDTs of OSH prepared using SD with CP seems to be promising formulations.

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    Suthar, R. M., Chotai, N. P., & Shah, D. D. (2013). Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Superdisintegrants. Indian Journal of Pharmaceutical Education and Research, 47(3), 49-55. https://doi.org/10.5530/ijper.47.3.8

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0