Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity
1, 1, 1, 2
- 1Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, Health Sciences Campus, Kochi-682041, Kerala, India.
- 2Sophisticated Analytical Instrumentation Facility, Indian Institute of Technology, Madras, Chennai-600036, Tamil Nadu, India.
CORRESPONDENCE
Ranganathan Balasubramanian
Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham University, Health Sciences Campus, Kochi-682041, Kerala, India.
Volume 47, Issue 4 · pp. 31-48 · 2014 · DOI: 10.5530/ijper.47.4.5
ABSTRACT
A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative.
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Balasubramanian, R., Iqbal, H., Gopal, R. V., & Baby, C. (2014). Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity. Indian Journal of Pharmaceutical Education and Research, 47(4), 31-48. https://doi.org/10.5530/ijper.47.4.5
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© 2014 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0