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Pre-Clinical Evolutionary Study of Alpha-Pinene in L-Arginine Induced Acute Pancreatitis in Rat.

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  1. 1Jagdishprasad Jhabarmal Tibrewala University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu, Rajasthan-333001 Department of Pharmacology, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad 500 028, India.

CORRESPONDENCE

Sandeep Biradar, *Jagdishprasad Jhabarmal Tibrewala

University, Vidyanagari, Churu Jhunjhunu Road, Chudela, District-Jhunjhunu, Rajasthan-333001 Department of Pharmacology, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad 500 028, India.

sandeepbiradar84@gmail.com

Volume 47, Issue 4 · pp. 73-78 · 2014 · DOI: 10.5530/ijper.47.4.10

ABSTRACT

Objective: Screening of alpha-pinene on L-arginine induced acute pancreatitis model.Material and Methods: In this model the acute pancreatitis was determined at 24h by determination of pancreatic wet weight/body weight ratio, nitrate/nitrite levels, lipid peroxidation (thiobarbituric acid reactive substances (TBARS)], proinflammatory cytokines [tumor necrosis factor (TNF)-α, C-reactive proteins (CRP) and interleukin (IL)], pancreatic myeloperoxidase (MPO) activity and serum levels of amylase and lipase.Results: Administration of L-arginine had induced pancreatitis and this was characterized by pulmonary complication including altered pancreatic wet weight/body weight ratio, nitrate/nitrite levels, proinflammatory cytokines, TBARS, MPO and serum levels of amylase and lipase. Treatment with alpha-pinene (100 and 200mg/kg) dose significantly attenuated the L-arginine-induced pancreatitis and related complication.Conclusion: The histological findings proved the amelioration of pancreatic injury by alphapinene and biochemical parameters proved anti-inflammatory and antioxidant property of alpha-pinene.

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    Biradar, S., & B, V. (2014). Pre-Clinical Evolutionary Study of Alpha-Pinene in L-Arginine Induced Acute Pancreatitis in Rat.. Indian Journal of Pharmaceutical Education and Research, 47(4), 73-78. https://doi.org/10.5530/ijper.47.4.10

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    © 2014 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0