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Anthocyanin Improving Metabolic Disorders in Obese Mice from Aornia melanocarpa

1, 1, 1, 2, 2, 2

  1. 1School of Life Science, Liaoning University, Shenyang 110036, CHINA.
  2. 2Foresty Science Research Institute of Liaoning Province, Shenyang, CHINA.

CORRESPONDENCE

Jie Wei

School of Life Science, Liaoning University, Shenyang 110036, CHINA.

weijie@lnu.edu.cn

Received: 24-12-2015; Accepted: 29-02-2016.

Volume 50, Issue 3 · pp. 368-375 · 2016 · DOI: 10.5530/ijper.50.3.8

ABSTRACT

The aim of this study was to investigate the effects of Aornia melanocarpa anthocyanin (AMA) on symptoms of metabolic syndrome in obese mouse. AMA can reduce weight. Blood glucose and lipid metabolism were significantly improved, and so as hepatic lipid metabolism. This suggesting AMA is a strong indication of improved glucose lipid metabolism and weight. Moreover, both morphologic and histological detections indicated that AMA significantly reversed obsity induced hepatic steatosis and liver injury. Furthermore, AMA significantly ameliorated inflammatory cytokines including both IL-6 and TNF-α in liver and fatty tissue. Moreover, insulin receptor (IR), p-IRS and p-AKT that associated proteins about glucose-lipid metabolism signaling pathway were markedly up-regulated at protein levels by AMA. Our results demonstrate that Aornia melanocarpa anthocyanin treatment can alleviate obsity and metabolic syndrome. The beneficial effects of AMA are associated with improved glucose-lipid metabolism and reduced levels of inflammatory cytokines.

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    Wei, J., Zhang, G., Zhang, X., gao, J., Fan, J., & Zhou, Z. (2016). Anthocyanin Improving Metabolic Disorders in Obese Mice from Aornia melanocarpa. Indian Journal of Pharmaceutical Education and Research, 50(3), 368-375. https://doi.org/10.5530/ijper.50.3.8

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    © 2016 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0