Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

The Release of Doxorubicin’s Active Ingredient from the Hydrogels with Poly (HEMA/Acrylamide/ Itaconic acid) and Their Biological Function

1

  1. 1Department of Science Education. Erciyes University, Education Faculty Primary Education, KAYSERİ.

CORRESPONDENCE

Ishak Afşin Karipe

Department of Science Education. Erciyes University, Education Faculty Primary Education, KAYSERİ.

akariper@gmail.com

Received: 04-01-2017; Accepted: 30-03-2017.

Volume 51, Issue 3 · pp. 401-406 · 2017 · DOI: 10.5530/ijper.51.3.67

ABSTRACT

In this study, Poly (HEMA/Acrylamide/ Itaconic acid) (HAI) polymer was synthesized for using in the release of Doxorubicin drug. Poly (HEMA/acrylamide/Itaconic acid) (HAI) hydrogel was prepared by a radical addition reaction in aqueous media formed by HEMA, acrylamide, Itaconic acid, in the presence of TEMED (N,N,N’,N’-tetramethylenediamine). The characterization of the polymer was performed by FTIR analysis. At the same time, swelling and drug absorption capabilities of the polymers were analyzed. It has been observed that the entire drug, which was added to the solution with 0.1 mg of polymer, was absorbed in around 25 hours. This measurement showed that the absorption of this polymer is quite high compared to many polymers in the literature. Moreover, this polymer showed 80% swelling at 1000 minutes. In the light of these results, it has been concluded that this new polymer is very suitable for the release of Doxorubicin drug.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Kariper, I. A. (2017). The Release of Doxorubicin’s Active Ingredient from the Hydrogels with Poly (HEMA/Acrylamide/ Itaconic acid) and Their Biological Function. Indian Journal of Pharmaceutical Education and Research, 51(3), 401-406. https://doi.org/10.5530/ijper.51.3.67

    Copyright and licence

    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0