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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats

1, 2, 1, 1, 1, 3, 1, 4, 5, 6

  1. 1Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.
  2. 2Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, PAKISTAN.
  3. 3Department of Pharmacy, University of Malakand, Chakdara Dir, Khyber Pakutunkhwa, PAKISTAN.
  4. 4Department of Biochemistery, Abdul Wali Khan University Mardan, 23200, Khyber Pakutunkhwa, PAKISTAN.
  5. 5Department of Plant Breeding and Genetics, .
  6. 6Department of Physics Government College University Faisalabad, .

CORRESPONDENCE

Rahmat Ali Khan

Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Khyber Pakutunkhwa, PAKISTAN.

rahmatgenetics@gmail.com

Received: 13-12-2016; Accepted: 15-02-2017.

Volume 51, Issue 3 · pp. 412-417 · 2017 · DOI: 10.5530/ijper.51.3.69

ABSTRACT

Background: Rutin, a polyphenolic flavonoid, possesses antioxidant and hypoglycemic effects.Objective: The present study was conducted to check the effect of rutin on serum reproductive hormonal level and sperm concentration in male rat.Methods: 30 rats were equally divided into 3 groups (10 rats per group). Group I was control (untreated), group II was given rutin 50 mg/kg bw while group III was given 100 mg/ kg bw intragastric twice a week for four weeks respectively. The effect of rutin on antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents and TBARS contents were checked.Results: The results revealed that rutin caused significant gain in body weight, antioxidant enzymes (POD, SOD, GSHpx, GST, GSR), glutathione contents, with significant (P< 0.01) decrease in thiobarbituric acid reactive substance (TBARS) concentrations.Conclusion: It may be concluded that rutin may be promising as a natural therapeutic agent in male reproductive dysfunction.

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    Khan, R. A., Khan, M. R., Ahmed, M., Shah, M. S., Rehman, S. U., Khan, J., Husain, M., Khan, F. A., Khan, M. M., & Shifa, M. S. (2017). Effects of Rutin on Testicular Antioxidant Enzymes and Lipid Peroxidation in Rats. Indian Journal of Pharmaceutical Education and Research, 51(3), 412-417. https://doi.org/10.5530/ijper.51.3.69

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    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0