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In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline

1, 2, 3

  1. 1Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
  2. 2Departmentof Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.
  3. 3Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan University, Bhubaneswar, Orissa, INDIA.

CORRESPONDENCE

SahooJyotirmaya

Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, Orissa, INDIA.

jjyotisahoo@rediffmail.com

Received: 07-12-2016; Accepted: 15-02-2017.

Volume 51, Issue 3 · pp. 480-489 · 2017 · DOI: 10.5530/ijper.51.3.76

ABSTRACT

Introduction: Novel Cu(II), Co(II) and Ni(II) complexes of 8-hydroxyquinolineazo analogues are synthesized from 5-((3-nitrophenyl)diazenyl) quinolin-8-ol (4a) and 5-((4-bromo-3- methylphenyl) diazenyl) quinolin-8-ol (4b).Methods: The structural environment and elemental composition of the synthesized metal complexes are confirmed by FT/IR, 1H NMR and CHNS/O elemental analyzer. The λmax and molecular mass are determined with the help of UV-visible and LC-MS spectrometer.Results: The magnetic susceptibility study suggested that the synthesized complexes are proposed with tetrahedral geometry. Among the six complexes, the bis bis 8, 8′ [5-((3-nitrophenyl) diazenyl) quinolinium] copper (4aLig2Cu) and bis 8, 8′ [5-((4-bromo-3-methylphenyl) diazenyl) quinolinium] copper (4bLig2Cu) showed significant antimicrobial activity.Conclusion: It was found that the metal complexes showed enhanced antimicrobial activity in comparison to their corresponding ligands.

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    Jyotirmaya, S., Nandini, S. P. K., & Kumar, P. S. (2017). In vitro Antimicrobial Investigations of Newly Synthesized Transitional Bivalent Metal Complexes Derived from 8-Hydroxyquinoline. Indian Journal of Pharmaceutical Education and Research, 51(3), 480-489. https://doi.org/10.5530/ijper.51.3.76

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    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0