The Involvement of NO–cGMP–ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia
1, 1
- 1Anadolu University Faculty of Pharmacy Department of Pharmacology Eskisehir, 26470, TURKEY.
CORRESPONDENCE
Bektas Nurcan
Anadolu University Faculty of Pharmacy Department of Pharmacology Eskisehir, 26470, TURKEY.
Volume 51, Issue 3s2 (Supplement) · pp. s355-s358 · 2017 · DOI: 10.5530/ijper.51.3s.46
ABSTRACT
Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory activities have been identified. However, the studies focused on the analgesic effect of protocatechuic acid are limited and the action mechanisms of PCA still remain unclear. The NO-cGMP-ATP-sensitive K+ channels pathway is one of the mechanism of action for various analgesic drugs. The present study was conducted to investigate the involvement of NO–cGMP–ATP sensitive K+ channels pathway in analgesic effect of p.o. administration of 300 mg/kg protocatechuic acid in acetic acid-induced writhing test in mice. It was shown that pre-treatment with glibenclamide (10 mg/kg, i.p.), an ATPsensitive K+ channel blocker, and methylene blue (20 mg/kg, i.p.), a guanylate cyclase inhibitor, did not notably change antinociception produced by 300 mg/kg protocatechuic acid, however administration of nitro-L-arginine methyl ester (10 mg/kg, i.p.), a nitric oxide synthase inhibitor, significantly reversed protocatechuic acid antinociception. The results show that the peripheral mechanism of action of protocatechuic acid-induced antinociception involved another nitric oxide related pain pathway, not NO–cGMP–ATP sensitive K+ channels pathway.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Nurcan, B., & Rana, A. (2017). The Involvement of NO–cGMP–ATP Sensitive K+ Channels Pathway in Protocatechuic Acid Peripheral Analgesia. Indian Journal of Pharmaceutical Education and Research, 51(3s2), s355-s358. https://doi.org/10.5530/ijper.51.3s.46
Copyright and licence
© 2017 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0