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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Micellar Properties and Antimicrobial Activityof a Mixed Surfactant System Constituted by Sodium Dodecyl Sulfate and Cetylpyridinium Chloride

1, 1

  1. 1Faculty of Sciences, Department of Chemistry, Gazi University, Ankara 06500, TURKEY.

CORRESPONDENCE

Deniz Şahin Taş

Faculty of Sciences, Department of Chemistry, Gazi University, Ankara 06500, TURKEY.

dennoka1k@hotmail.com

Received: 16-09-2016; Accepted: 30-03-2017.

Volume 51, Issue 4 · pp. 580-587 · 2017 · DOI: 10.5530/ijper.51.4.87

ABSTRACT

Objective: Micellar properties of sodium dodecyl sulfate (NaDS) was examined in the presence of cetylpyridinium chloride (CPC) by means of surface tension, viscosity, dye solubilization, cloud point (CP) measurements.Antimicrobial activities of single and binary systems were also investigated.Results: A decrease in critical micelle concentration (CMC) and increase in solubilizing power for NaDS was observed with increasing CPC concentration. At the highest CPC concentration studied (0.1 M), the surface tension decreased up to 51 mN / m.Also, viscosity results showed growth in NaDS micelles (50 mM) up to the 0.1 M CPC concentration. Antimicrobial activity of NaDS, CPC and NaDS in presence of CPC was investigated against ten different strains of bacteria and ayeast which was not investigated up to now. The susceptibilities of the microorganism were determined by the agar diffusion method. The results showed that NaDS and CPC have a antimicrobial activity but NaDS in presence of CPC has not antimicrobial activity on the bacterial and yeast.

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    Taş, D. A., & Çete, S. (2017). Micellar Properties and Antimicrobial Activityof a Mixed Surfactant System Constituted by Sodium Dodecyl Sulfate and Cetylpyridinium Chloride. Indian Journal of Pharmaceutical Education and Research, 51(4), 580-587. https://doi.org/10.5530/ijper.51.4.87

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    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0