Matrix Tablet Containing Quaternary Inclusion Complex of Domperidone for Treatment of Diabetic Gastroparesis

ABSTRACT

Objective: The present investigation is aimed at development and optimization of a pH independent controlled release matrix tablet containing mannitol based quaternary inclusion complex (QIC) of domperidone (DOM) for the treatment of diabetic gastroparesis.Methods: The tablets were prepared by direct compression and central composite design was used to optimize the amount of sodium alginate (SA) and hydroxypropylmethylcellulose (HPMC) to obtain a final formulation with desired release characteristics. The drug release from the optimized formulation was compared with the tablets containing pure DOM, binary and ternary inclusion complexes. Results and Discussion: The formulations showed a zero order release profile. The design models suggested greater influence of SA on the drug release. The optimized formulation showed minimum burst effect and released 88.65±3.19% DOM at the end of 12 h. The comparative study revealed that the optimized formulation exhibited nearly complete release of DOM.Conclusion: It was concluded that the optimized formulation containing QIC may reduce the dose frequency and improve the bioavailability of DOM.

KEYWORDS

• Quaternary inclusion complex
• pH independent controlled release
• Domperidone
• Central composite design
• Diabetic gastroparesis

Showing references and in-text citations exactly as published.

• DOI10.5530/ijper.51.4s.87Copy

Copyright and licence

© 2017 Author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0

RELATED ARTICLES

Matched on section and article type within this issue of IJPER.

• Article · VOLUME 51, ISSUE 4S (SUPPLEMENT)Development and Evaluation of Fast Dissolving Film for Oro-Buccal Drug Delivery of ChlorpromazineMd Wasim Hussain, Poonam Kushwaha, Md. Azizur Rahman, Juber Akhtar · pp. s539-s547Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4S (SUPPLEMENT)Process Optimization of Methylphenidate Hydrochloride Extended Release Pellets by QbDBala Vishnu Priya Mukkala, Murthy TEGK, Prameela Rani A · pp. s548-s558Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4S (SUPPLEMENT)Nephroprotective Effect of Low Viscosity Sodium Alginate on Lead Acetate-Induced Nephrotoxicity in RatsGagandeep Kaur, Saurabh Sharma · pp. s559-s565Original ArticleSame type: Article
• Article · VOLUME 51, ISSUE 4S (SUPPLEMENT)Enhancement of Paclitaxel Oral Bioavailability in Swiss Mice by Four Consecutive Days of Pre-Treatment with CurcuminAnjna Sharma, Asmita Magotra, Utpal Nandi, Gurdarshan Singh · pp. s566-s570Original ArticleSame type: Article