Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Synthesis and Characterization of 2-phenyl-5- (1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials

1,2, 3

  1. 1Department of Chemistry, Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, INDIA.
  2. 2Escientia Bio Pharma Pvt Ltd, ICICI Knowledge Park, Hyderabad, Telangana, INDIA.
  3. 3Department of Chemistry, Pragati Engineering College (A), Surampalem, Andhra Pradesh, INDIA.

CORRESPONDENCE

Venkata Sathya Machiraju Palagummi

Department of Chemistry, Pragati Engineering College (A), Surampalem, Andhra Pradesh, INDIA.

drpvsm.res@gmail. com

Received: 16-07-2017; Accepted: 10-01-2018.

Volume 52, Issue 1 · pp. 135-145 · 2018 · DOI: 10.5530/ijper.52.1.15

ABSTRACT

Objective: The present research is aimed at the discovery and development of 1-phenyl-3- (3,4,5-trimethoxyphenyl)-1H-pyrazole derivatives as a series of novel 1, 3, 4-oxadiazoles (7a-7h) through iodine-catalyzed oxidative cyclization of the hydrazone derivatives (6a6h) in the presence of potassium carbonate as base and DMSO as solvent in good toexcellent yields.Methods: The structures of all the newly synthesized compounds (6a6h) and(7a-7h) were well characterized by IR, 1H NMR, 13C NMR and HRMS. Furthermore, allthe synthesized compounds (6a-6h and 7a-7h) were evaluated for their antimicrobial andanti-oxidant activities.Results: The research results revealed that the compound 6d (Z)-2-bromo-N'-((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide) has antimicrobial potent while the synthesized compounds 6a (Z)-N'- ((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide), 6e (Z)-2, 5-dichloro-N'-((1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl) methylene) benzohydrazide), 7e (2-(2, 5-dichlorohenyl)-5-(1-phenyl-3-(3, 4, 5-trimethoxyphenyl)- 1H-pyrazol-4-yl)-1, 3, 4-oxadiazole) and 7f (2-(3, 5-dichlorophenyl)-5-(1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol-4-yl)-1, 3, 4-oxadiazole) exhibited strong antioxidant activity compared to the control BHT.Conclusion: The novel hydrazonessynthesized and 1, 3, 4 oxadiazole derivatives may be suggested for their establishment in chemical class of antimicrobial and antioxidant agents in new drug discovery and medicinal research.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Chennapragada, K. P., & Palagummi, V. S. M. (2018). Synthesis and Characterization of 2-phenyl-5- (1-phenyl-3-(3, 4, 5-trimethoxyphenyl)-1H-pyrazol4-yl) - 1, 3, 4-oxadiazole Scaffolds for Assessing Their Medicinal Potentials. Indian Journal of Pharmaceutical Education and Research, 52(1), 135-145. https://doi.org/10.5530/ijper.52.1.15

    Copyright and licence

    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0