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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Pharmacokinetics and Tissue Distribution of PLGAPLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS

1, 1, 1,2, 1

  1. 1College of Pharmacy, Nanjing Tech University CHINA.
  2. 2Nanjing Bestform Pharmaceutical Technology Co, Ltd CHINA.

CORRESPONDENCE

Yonglu Wang

College of Pharmacy, Nanjing Tech University CHINA.

wl_761107@163.com

Received: 26-05-2017; Accepted: 25-09-2017.

Volume 52, Issue 1 · pp. 42-53 · 2018 · DOI: 10.5530/ijper.52.1.5

ABSTRACT

Objective: A sensitive, rapid and reliable LC-MS/MS method was developed for simultaneously determination of daunorubicin (DNR) and tetrandrine (Tet) in rat plasma and tissues.Methods: The pharmacokinetics and tissue distribution of DNR/Tet-PLGAPLL-PEG-NPs-Tf (D/T-PPP-NPs-Tf), DNR/Tet-PLGA-PLL-PEG-NPs (D/T-PPP-NPs) and DNR/Tet (D/T) solution were compared following intravenous injection in the rats.Result: Compare to D/T solution, the parameters of DNR and Tet in D/T-PPP-NPs-Tf group presented significantly higher AUC (p<0.01) and lower V (p<0.05). Compared with D/T solution, the distribution of DNR in groups of D/T-PPP-NPs and D/T-PPP-NPs-Tf were higher in liver (p<0.01), lung (p<0.05), fat (p<0.05) and testicle (p<0.05), and were lower in heart, spleen, kidney (p<0.01), brain and intestine (p<0.01). The distribution of Tet in D/T-PPP-NPs and D/T-PPP-NPs-Tf groups were higher in liver, brain and uterus (p<0.05), and were lower in heart, spleen, lung, kidney and fat (p<0.05) compared with D/T solution.Conclusion: The LC-MS/MS method was specific, sensitive, rapid and reliable for the simultaneously determination of DNR and Tet in rat plasma and tissues. Compared with D/T solution, D/T-PPP-NPs-Tf tended to stay in the blood after injection. The distribution of D/T-PPP-NPs and D/T-PPP-NPs-Tf were significantly changed.

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    Wang, Y., Li, Y., Liu, J., & Li, X. (2018). Pharmacokinetics and Tissue Distribution of PLGAPLL-PEG-TF Nanoparticles Loaded with Daunorubicin and Tetrandrine Following Intravenous Injection in the Rats Using LC-MS/MS. Indian Journal of Pharmaceutical Education and Research, 52(1), 42-53. https://doi.org/10.5530/ijper.52.1.5

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    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0