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Factorial Design Methodology for Development of Pediatric Nasal Spray: Study on Xylometazoline Nasal Solution Used For Treatment of Nasal Congestion

1, 1, 1

  1. 1Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat -387001, India.

CORRESPONDENCE

Falgun Bhuva

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat -387001, India.

falgun_001@yahoo. co.in

Received: 03-08-2016; Accepted: 23-11-2016.

Volume 52, Issue 2 · pp. 218-229 · 2018 · DOI: 10.5530/ijper.52.2.25

ABSTRACT

Objective: The objective of the present work is to develop the meter dose pediatric formulation of xylometazoline hydrochloride for enhanced effectiveness for nasal decongestion. Experimental Work: The 32 factorial experimental design was employed for optimization of sodium cholate (X1) and Polyethyleneglycol 400 concentration (X2) in the formulation. The optimized formulation contains 1.18 % w/v sodium cholate and 13 % v/v Polyethyleneglycol 400. The formulation was further evaluated for its drug content, pH, viscosity, spray content uniformity, In vitro-diffusion studies, pump delivery, spray pattern, sterility and stability study.Results: The percentage diffusion and viscosity was observed 91.33 ± 1.15 % and 19.33 ± 0.57 centipoise respectively. The meter dose nasal formulation shows the superior performance during in-vitro drug release compared with current marketed formulations, which provides alternative option for treatment of nasal decongestion.

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    Bhuva, F., Patel, L. D., & Patel, K. (2018). Factorial Design Methodology for Development of Pediatric Nasal Spray: Study on Xylometazoline Nasal Solution Used For Treatment of Nasal Congestion. Indian Journal of Pharmaceutical Education and Research, 52(2), 218-229. https://doi.org/10.5530/ijper.52.2.25

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    © 2018 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0