Synthesis and Anti-Inflammatory Activity Evaluation of 5-(1-Benzyl-1H-[1,2,3]Triazol-4-yl)-4-Phenyl4H-[1,2,4]Triazole-3-Thiol Derivatives
1, 1,2, 1,2, 1,2
- 1Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P.R. CHINA.
- 2Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao, Inner Mongolia, P.R. CHINA.
CORRESPONDENCE
Chengxi Wei
Medicinal Chemistry and Pharmacology Institute, Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia, P.R. CHINA.
Received: 26-11-2017; Accepted: 28-01-2018.
Volume 52, Issue 3 · pp. 505-513 · 2018 · DOI: 10.5530/ijper.52.3.58
ABSTRACT
Context: Aims: In order to search new compounds with higher anti-inflammatory activities and lower toxicity. 1,2,3-triazole and 1,2,4-triazole derivatives were designed and synthesized, and then the anti-inflammatory activities (in vitro) were evaluated. Settings and Design: The triazole derivatives were designed on the basis of association principle.Methods and Material: 19 benzo[d]-5-(1-Benzyl-1H-[1,2,3]triazol-4-yl)-4- phenyl-4H-[1,2,4]triazole-3-thiol derivatives were synthesized and evaluated for their bioactivities in vitro as anti-inflammatory agents. Statistical analysis used: Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by a least signifcant difference (LSD) test for multiple comparisons, using SPSS version 17.0 statistical software.Results: The results of this study indicated that compound 17(1-Benzyl-4-[5-(4-chloro-phenylsulfanyl)-4-phenyl-4H-[1,2,4]triazol-3-yl]-1H-[1,2,3] triazole) showed excellent inhibition on the expression of IL-6 among these compounds in LPS-induced RAW 264.7 macrophage cell.Conclusion: The findings of this study showed that compound 17 showed excellent inhibition on the expression of IL-6 in LPSinduced macrophage cells. Further studies are warranted to investigate the mechanism of anti-inflammation, in order to represent a novel strategy for the modulation of inflammatory responses.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Liu, C., Bian, M., Yu, L., & Wei, C. (2018). Synthesis and Anti-Inflammatory Activity Evaluation of 5-(1-Benzyl-1H-[1,2,3]Triazol-4-yl)-4-Phenyl4H-[1,2,4]Triazole-3-Thiol Derivatives. Indian Journal of Pharmaceutical Education and Research, 52(3), 505-513. https://doi.org/10.5530/ijper.52.3.58
Copyright and licence
© 2018 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0