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Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats

1, 1

  1. 1Department of Pharmacology, Faculty of.

CORRESPONDENCE

Anita Murali

Department of Pharmacology, Faculty of Pharmacy, M. S. Ramaiah University of Applied Sciences, MSRIT Post, MSR Nagar, Bangalore- 560054, Karnataka, INDIA.

anita.murali4@gmail.com

Received: 11-07-2018; Accepted: 29-12-2018.

Volume 53, Issue 2 · pp. 261-267 · 2019 · DOI: 10.5530/ijper.53.2.34

ABSTRACT

Aim: The aim of this study was to investigate the aldose reductase inhibition and anti-cataract property of W. volubilis root extract in rats with streptozotocin induced diabetes mellitus.Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin at the dose of 45 mg/kg. Diabetic animals were treated with glimepiride (0.5 mg/kg) and alcohol extract at 100 and 200 mg/kg for 38 d. Lens were isolated and certain markers were estimated.Results: Treatment of diabetic animals with alcohol extract of W. volubilis root inhibited aldose reductase activity (p < 0.001) and sorbitol formation in the lens. Additionally, a reduction in the levels of MDA, GSH, SDH and LDH in extract treated groups was observed. There was an overall decrease in the severity of cataract progression.Conclusion: The result provided evidence that alcohol extract of W. volubilis root prevents the development of diabetic cataract in rats.

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    Haroon, H. B., & Murali, A. (2019). Alcohol Extract of Wattakaka volubilis (L.F) Stapf Root Inhibits Aldose Reductase to Prevent Diabetes Associated Cataract Formation in Rats. Indian Journal of Pharmaceutical Education and Research, 53(2), 261-267. https://doi.org/10.5530/ijper.53.2.34

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0