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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP

1, 1, 1

  1. 1Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.

CORRESPONDENCE

Ashlesha Pravin Pandit

Department of Pharmaceutics, JSPM Rajarshi Shahu College of Pharmacy and Research, Tathawade, Pune, Maharashtra, INDIA.

panditashleshap@rediffmail.com

Received: 04-12-2018; Accepted: 22-04-2019.

Volume 53, Issue 3 · pp. 457-467 · 2019 · DOI: 10.5530/ijper.53.3.78

ABSTRACT

Objective: An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology.Methods: Liquisolid tablet was formulated using non-volatile solvent Transcutol HP, carrier material Neusilin US2 and coating material Aerosil 200. Appropriate quantities of excipients were calculated with the help of mathematical model to get liquisolid powder. A 32 full-factorial design was used further to optimize liquisolid powder.Results: DSC, XRD and SEM studies revealed absence of crystalline nature of drug in liquisolid powder. Liquisolid powder was further compressed into tablet and subjected to various evaluation tests such as in-vitro drug release and ex-vivo intestinal permeation study.Conclusion: Liquisolid technology was found to be promising due to enhance solubility, dissolution and permeation of candesartan cilexetil by 19.75, 3.09 and 2.4-fold, respectively.

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    Argade, P., Patole, V. C., & Pandit, A. P. (2019). Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP. Indian Journal of Pharmaceutical Education and Research, 53(3), 457-467. https://doi.org/10.5530/ijper.53.3.78

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0