Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

QbD Based Optimization of Curcumin Nanoemulsion: DoE and Cytotoxicity Studies

1, 2, 1, 3

  1. 1Department of Quality Assurance Techniques, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Maharashtra, INDIA.
  2. 2Department of Drug Regulatory Affairs, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, INDIA.
  3. 3Department of Pharmaceutics, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, INDIA.

CORRESPONDENCE

Varsha Babu Pokharkar

Department of Pharmaceutics, Bharati Vidyapeeth (Deemed to be University), Poona College of Pharmacy, Erandwane, Pune, Maharashtra, INDIA.

varsha.pokharkar@bharatividyapeeth.edu

Received: 21-08-2019; Accepted: 23-01-2019.

Volume 54, Issue 2 · pp. 329-336 · 2020 · DOI: 10.5530/ijper.54.2.38

ABSTRACT

Aim: The aim of this study was to employ a Quality by design (QbD) based approach for the development and optimization of stable curcumin (CUR) nanoemulsion (NE).Materials and Methods: The NE was developed using Tween 80 as surfactant, Tocopheryl polyethylene glycol 1000 succinate (TPGS) as cosurfactant and Kollisolv MCT 70 as oil phase. The Design of Experiment (DoE) consisted of a 3 level- 2 factor full factorial design for the optimization. The independent variables were concentration of surfactant mix (Smix) and oil phase while particle size, zeta potential and polydispersity index (PDI) were the dependent variables. The NE was evaluated for particle size, zeta potential, pH, viscosity, transmittance, drug content, in-vitro drug release, stability and in vitro anticancer activity.Results: The optimized formulation showed approximate particle size of 17nm, zeta potential -12.8 and polydispersity index 0.161 and was stable for three months at room temperature. The nanoemulsion showed better activity as compared to pure drug against pituitary and colon cancer cell-lines.Conclusion: QbD based approach can aid in the development of robust and thermodynamically stable NEs.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Acharya, S. D., Tamane, P. K., Khante, S. N., & Pokharkar, V. B. (2020). QbD Based Optimization of Curcumin Nanoemulsion: DoE and Cytotoxicity Studies. Indian Journal of Pharmaceutical Education and Research, 54(2), 329-336. https://doi.org/10.5530/ijper.54.2.38

    Copyright and licence

    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0