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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents

1, 2, 3, 4, 3, 5, 4

  1. 1Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
  2. 2Pharmacology Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.
  3. 3Department of Pharmaceutical Analysis, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Krishna, Andhra Pradesh, INDIA.
  4. 4Department of Pharmaceutics, V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Krishna, Andhra Pradesh, INDIA.
  5. 5Department of Pharmacology, Institute of Pharmaceutical technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, INDIA.

CORRESPONDENCE

Dintakurthi Sree Naga Bala Krishna Prasanth

Pharmacognosy Research Division, K L College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Guntur, Andhra Pradesh, INDIA.

dsnbkprasanth@kluniversity.in

Received: 04-01-2020; Accepted: 30-04-2020.

Volume 54, Issue 2s (Supplement) · pp. s251-s260 · 2020 · DOI: 10.5530/ijper.54.2s.81

ABSTRACT

Background: The current study assesses the anthelmintic impact of root extracts of Pavetta tomentosa on Pheretima posthuma compiled by molecular docking analysis of phytocompounds steemed from the plant with the β-Tubulin (PDB ID: 1SA0).Methods: In this study, P. tomentosa root was subjected to extraction using methanol and water. In vitro, anthelmintic activity was assessed by utilizing the Pheretima posthuma and in silico molecular docking was executed making use of Autodock 4.0.Results: The outcomes revealed that the methanolic extract has the most significant dose-dependent anthelmintic activity at various doses, followed by aqueous extracts of root. Amongst all the substances, β-eudesmol revealed the most effective docking rating of -6.53, which is nearer to Albendazole, i.e., -6.79, ensuring that β-eudesmol has a strong binding fondness in between protein and ligand.Conclusion: From the examinations, a conclusion can be drawn that the anthelmintic activity of P. tomentosa root in both in vitro and insilico assays. The information sustains β-eudesmol to be a useful anthelmintic compound beneficial to future clinical examinations.

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    Prasanth, D. S. N. B. K., Panda, S. P., Rao, A. L., Teja, N., Vani, V. B. N., Sandhya, T., & Rao, P. B. B. (2020). In vitro Anthelmintic Impact of Various Extracts of Pavetta tomentosa Root on Pheretima posthuma and in-silico Molecular Docking Evaluation of some Isolated Phytoconstituents. Indian Journal of Pharmaceutical Education and Research, 54(2s), s251-s260. https://doi.org/10.5530/ijper.54.2s.81

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    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0