Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization

1,9, 2, 1, 3, 4, 1, 1, 1,10, 1,8, 5, 6, 7

  1. 1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
  3. 3Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  4. 4Department of Chemistry, College of Science, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  5. 5Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  6. 6Department of Pharmacognosy, PA College of Pharmacy, Mangalore, Karnataka, INDIA.
  7. 7School of Pharmacy, Monash University, Jalan Lagoon Selatan, Bandar Sunway, Selangor, MALAYSIA.
  8. 8Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia 61511, EGYPT.
  9. 9Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, INDIA.
  10. 10Department of Biotechnology and Food Technology, Durban University of Technology, Durban, SOUTH AFRICA.

CORRESPONDENCE

Nagaraja Sreeharsha

Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.

sharsha@kfu.edu.sa

Received: 29-02-2020; Accepted: 30-03-2020.

Volume 54, Issue 3 · pp. 826-834 · 2020 · DOI: 10.5530/ijper.54.3.135

ABSTRACT

Background: Doxorubicin is an excellent molecule for the formation of biodegradable implants using the poly (sebacic acid-co-ricinoleic-ester anhydride) 70:30 w/w (poly[SARA] 70:30 w/w PSRA 7/3) polymer.Methods: The cylindrical implants were successfully produced by means of hot melt extrusion. We used differential scanning calorimetric (DSC) and X-ray diffraction (XRD) methods to identify the melting state and crystal type of blank and drug-loaded implants. A study was conducted on PSRA 7/3 w/w blank and drug-loaded implants for in vitro hydrolytic degradation. The drug present in the remaining sample was estimated.Results: The hydrolytic degradation rate of the 10% w/w (F2)-loaded implant was relatively low when compared with the 20% w/w (F3) implant.Discussion: In vitro drug release studies illustrated that the drug-release rate was faster in association with increasing amounts of doxorubicin in the implant.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sreeharsha, N., Hiremath, J. G., Al-Dhubiab, B. E., Meravanige, G., Karnati, R. K., Attimarad, M., Nair, A. B., Venugopal, K. N., Morsy, M. A., Pottathil, S., Khan, S., & Molugulu, N. (2020). Fabrication of Poly (Sebacic acid-co-ricinoleic-ester anhydride) with β-cyclodextrin-loaded Doxorubicin Implants and in vitro Characterization. Indian Journal of Pharmaceutical Education and Research, 54(3), 826-834. https://doi.org/10.5530/ijper.54.3.135

    Copyright and licence

    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0