SARS-CoV-2: The Prominent Role of Non-structural Proteins (NSPS) in COVID-19
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- 1College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, INDIA.
CORRESPONDENCE
Uma Sankar Gorla
College of Pharmacy, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, INDIA.
Received: 10-04-2020; Accepted: 13-08-2020.
Volume 54, Issue 3s (Supplement) · pp. s381-s389 · 2020 · DOI: 10.5530/ijper.54.3s.136
ABSTRACT
COVID-19, an infectious contagious viral (SARS-CoV-2) disease, associated with morbidity and mortality from respiratory pandemic worldwide. Currently, COVID-19 has no targeted treatment strategies and has been declared by WHO as a global health emergency. SARS-CoV-2, an enveloped, positive-sense, betacoronavirus (βCoV) spreading rapidly due to its potential pre- and asymptomatic transmission (silent transmission). The viral replicase single-stranded genome encodes for two open reading frame genes (orf1a and orf1b), that are translated into two polyproteins, pp1a and pp1b. Viral proteases including papain-like protease (PL-PRO) and chymotrypsin-like protease (3CL-PRO) pre-processes and fragments the polyproteins into 16 non-structural proteins (Nsps) that are assembled into replicase-transcriptase complex and exhibit multiple enzymatic activity. To rationalize their evolutionary success and develop improved control strategies, understanding the main functions and interactions of non-structural proteins of SARS-CoV-2 will be essential. Based on the existing published literature, this review summarizes the knowledge on multiple pathologic functions of Nsps in COVID-19. This review is hoped to help the researchers to understand the significant role of nonstructural proteins in COVID-19 and provide a reference for future studies.
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Gorla, U. S., & Rao, G. K. (2020). SARS-CoV-2: The Prominent Role of Non-structural Proteins (NSPS) in COVID-19. Indian Journal of Pharmaceutical Education and Research, 54(3s), s381-s389. https://doi.org/10.5530/ijper.54.3s.136
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This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0