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Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide

1,2

  1. 1Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.
  2. 2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.

CORRESPONDENCE

Muhammad Torequl Islam

Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, 700000, VIETNAM.

muhammad.torequl.islam@tdtu.edu.vn

Received: 19-04-2020; Accepted: 07-09-2020.

Volume 54, Issue 3s (Supplement) · pp. s580-s585 · 2020 · DOI: 10.5530/ijper.54.3s.157

ABSTRACT

Background: Andrographis paniculata and its main components andrographolide (AGL) have been reported for their promising cardio-protective effects in experimental animals.Aim: To investigate clot lysis activity of A. paniculata and AGL.Materials and Methods: The clot lysis activity of the aqueous A. paniculata stem extract (AAP) and AGL was investigated on clotted human blood by using streptokinase (SKE) as a standard drug.Results: Both AAP and AGL showed a concentration-dependent clot lysis activity. AAP showed the highest clot lysis activity at 100 μL (eq. 10% w/v) (54.12 ± 1.22%), while AGL showed at 100 μg/mL (58.62 ± 2.02%). The half maximal effective concentration (EC50) values of AAP and AGL were 87.32 ± 0.37 μL (eq. 8.732% w/v) and 79.74 ± 0.31 μg/mL, respectively. The netagive controls showed negligible clot lysis capacities, while the standard SKE showed 81.54 ± 0.78% clot lysis activity.Conclusion: AAP and its pure component NGL exhibited significant clot lysis activity on human clotted blood and may be good candidates for the treatment of atherothrombosis.

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    Islam, M. T. (2020). Clot Lysis Capacity of Andrographis paniculata and its Pure Compound Andrographolide. Indian Journal of Pharmaceutical Education and Research, 54(3s), s580-s585. https://doi.org/10.5530/ijper.54.3s.157

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    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0