Estimation of the Probability to Target Attainment to the Pharmacokinetic/ Pharmacodynamic Index of Ertapenem in Elderly Inpatients
1, 2, 2
- 1Department of Internal Medicine, University of Chile´s Clinical Hospital, Santiago, CHILE.
- 2Department of Pharmaceutical Science and Technology, Faculty of Chemistry and Pharmaceutical Sciences, University of Chile, Santiago, CHILE.
CORRESPONDENCE
Daniel Palma
Department of Internal Medicine, University of Chile´s Clinical Hospital, Santiago, CHILE.
Received: 11-02-2020; Accepted: 09-09-2020.
Volume 54, Issue 4 · pp. 1180-1183 · 2020 · DOI: 10.5530/ijper.54.4.215
ABSTRACT
Background: Infectious diseases are one of the most causes of hospitalization and death in adults in the elderly and this population is prone to develop complications and pharmacokinetic/pharmacodynamic changes.Objectives: To estimate the probability to target attainment (PTA) to the pharmacokinetic/pharmacodynamic (PK/ PD) index of ertapenem for older adults hospitalized in a medical ward.Materials and Methods: In a prospective and observational analysis, free drug concentrations of ertapenem were determined in older adults hospitalized at medical ward setting and compared with EUCAST epidemiological cut-off values (ECOFF: 0.064 mg/L) to extreme MIC (64 mg/L), using 1000 Monte Carlo simulations to estimate therapeutic target attainment (%f T ≥ MIC ≥ 40%).Results: Five elderly inpatients with renal impairment and hypoalbuminemia were included with eight samples per patient (n=40 observations). Monte Carlo simulations shown free ertapenem concentrations attain to PK/PD index on the MIC interval from 0.064 to 4 mg/L.Conclusion: If pathogen MICs are ≥ 4 mg/L, elderly inpatients could not attain to the PK/PD target of ertapenem in medical ward setting, rising probability of antimicrobial resistance and therapeutic failure in this population.
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Palma, D., Vega, E., & Gai, M. (2020). Estimation of the Probability to Target Attainment to the Pharmacokinetic/ Pharmacodynamic Index of Ertapenem in Elderly Inpatients. Indian Journal of Pharmaceutical Education and Research, 54(4), 1180-1183. https://doi.org/10.5530/ijper.54.4.215
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