Solubility Enhancement of Embelin by Complexation with Beta Cyclodextrin
1, 1
- 1Department of Pharmaceutics, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, Kerala, INDIA.
CORRESPONDENCE
Elizabeth N Xavier
Department of Pharmaceutics, Nirmala College of Pharmacy, Muvattupuzha, Ernakulam, Kerala, INDIA.
Received: 10-08-2020; Accepted: 12-04-2021.
Volume 55, Issue 2s (Supplement) · pp. s405-s413 · 2021 · DOI: 10.5530/ijper.55.2s.112
ABSTRACT
Introduction: Embelin, a phytoconstituent obtained from Embelia ribes of the Myrsinaceae family, has anti-cancer, anti-inflammatory, anti-bacterial, anti-fertility, analgesic, antidiabetic, anti-depressant and wound healing activities. It is hydrophobic in nature leading to low bioavailability.Aim: The present study aims to improve the water solubility and rate of dissolution of Embelin by complexation with β-cyclodextrin.Methods: Inclusion complexes were prepared by physical mixture, kneading and co-precipitation methods. Characterization of complexes was carried out by Fourier-Transform Infrared (FT-IR) spectroscopy and in vitro dissolution study. Differential scanning calorimetry (DSC) and Scanning electron microscopy (SEM) was used to analyze the prepared complexes prepared by the co-precipitation method. Antimicrobial studies of complexes against Staphylococcus aureus and Escherichia coli were carried out by colony counting method.Results: Phase solubility study showed Embelin forms complex with β-cyclodextrin in the ratio 1:2. FT-IR studies of complexes confirmed Embelin forms complex with β-cyclodextrin. DSC and SEM also confirmed the formation of a complex of Embelin with β-cyclodextrin. In vitro dissolution studies showed that the time to release 50 % (t50) of Embelin was in the order 15 min, 30 min, 60 min for complexes prepared by coprecipitation, kneading method and physical mixture respectively. Complexes prepared by the coprecipitation method showed 2 log reductions in the number of S. aureus and 1 log reduction in the number of E. coli in comparison with Embelin.Conclusion: Complexes of Embelin prepared by co-precipitation method resulted in largest percent drug content, enhanced aqueous solubility and antibacterial activity.
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Kani, J. K., & Xavier, E. N. (2021). Solubility Enhancement of Embelin by Complexation with Beta Cyclodextrin. Indian Journal of Pharmaceutical Education and Research, 55(2s), s405-s413. https://doi.org/10.5530/ijper.55.2s.112
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