Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate
1, 1,2, 1, 1
- 1Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, INDIA.
- 2School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, INDIA.
CORRESPONDENCE
Dr. Rajaram Mohapatra
Assistant Professor Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan, (Deemed to be University), Bhubaneswar-751003, Odisha, INDIA.
Received: 26-02-2021; Accepted: 02-07-2021.
Volume 55, Issue 3 · pp. 677-684 · 2021 · DOI: 10.5530/ijper.55.3.139
ABSTRACT
Purpose: Oral drug delivery system has always been a preferred choice for the treatment of peptic ulcer and gastroesophageal reflux diseases. Being a proton pump inhibitor omeprazole restricts gastric acid secretion but the foremost downside is its degradation in acidic environments. The systemic absorption of gastro-unstable drugs can be improved by the enteric coating.Materials and Methods: This study was aimed at developing an effective enteric coating for omeprazole tablets using HPMC E5-LV and Hydroxypropyl Methylcellulose Acetate Succinate (HPMC-AS) polymers. The core tablets were subcoated with HPMC E5-LV which acted as a barrier between core tablet and enteric coated tablet. The enteric coating was applied using HPMC-AS.Results: Dissolution information unveiled that the enteric coat remained in place for 2 hr in acidic medium (0.1N HCl) and later dissolved when came in contact with basic media (acetate buffer pH 6.8), it dissolved within a jiffy.Conclusion: The release profile showed 91 to 98% drug release within 1hr in pH 6.8 Acetate buffer. Further instrumental analysis was performed to ascertain drug-polymer interaction.
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Mohapatra, S. K., Sahoo, R. N., Mallick, S., & Mohapatra, R. (2021). Enteric Dissolution Enhancement of Engineered Gastro Resistant Omeprazole Tablets using Hydroxypropyl Methylcellulose Acetate Succinate. Indian Journal of Pharmaceutical Education and Research, 55(3), 677-684. https://doi.org/10.5530/ijper.55.3.139
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This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0