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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Effect of Formulation Variables on Fabrication of Risperidone Loaded Nanoparticles for Sustained Drug Delivery

1, 1, 1

  1. 1Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Vadodara, Gujarat, INDIA.

CORRESPONDENCE

Dipti Gohil

Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Vadodara, Gujarat, INDIA.

diptigohil2014@gmail.com

Received: 16-04-2021; Accepted: 28-07-2021.

Volume 56, Issue 1 · pp. 58-64 · 2022 · DOI: 10.5530/ijper.56.1.8

ABSTRACT

Aim/ Background: Risperidone, an atypical antipsychotic agent, is used in the treatment of psychotic disorders due to its lower Extra Pyramidal side Effects (EPS) than conventional antipsychotics.Materials and Methods: The objective of the present investigation is to study the effect of formulation variables using 32 factorial design; on preparation of nanoparticles to provide sustained drug release for a prolonged period of time; enhancing therapeutic efficacy by reducing dose dependent side effects. Study include formulation of nanoparticles by the nanoprecipitation method and optimization of the formulation parameters such as Amount of Polymer and Surfactant concentration as independent variables and Particle size and % entrapment efficiency as dependent variables using design of experiment; a statistical tool.Results: Optimized formulation of nanoparticles was characterized for various physicochemical parameters. The particle size was found to be 213.3 nm with 82.89% drug entrapment.Conclusion: In vitro drug release study and Pharmacodynamic study portend promising results of drug delivery for longer duration.

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    Gohil, D., Shah, N., & Maheshwari, R. A. (2022). Effect of Formulation Variables on Fabrication of Risperidone Loaded Nanoparticles for Sustained Drug Delivery. Indian Journal of Pharmaceutical Education and Research, 56(1), 58-64. https://doi.org/10.5530/ijper.56.1.8

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    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0