Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Development of Carmustine Loaded PLGA-PEG Conjugates for Nose to Brain Targeting

1,3, 2, 3, 3

  1. 1Research Scholar, Department of Pharmaceutics, Oriental University, Indore, Madhya Pradesh, INDIA.
  2. 2Faculty of Pharmacy, Department of Pharmacology, Oriental University, Indore, Madhya Pradesh, INDIA.
  3. 3Department of Pharmaceutics, SVKM’s Institute of Pharmacy, Dhule, Maharashtra, INDIA.

CORRESPONDENCE

Mrugendra Bhojraj Potdar

Research Scholar, Department of Pharmaceutics, Oriental University, Indore, Madhya Pradesh, INDIA.

mrugen.potdar@gmail.com

Received: 25-03-2022; Accepted: 10-08-2022.

Volume 56, Issue 4 · pp. 1076-1082 · 2022 · DOI: 10.5530/ijper.56.4.188

ABSTRACT

Intranasal drug delivery is a promising route for drug delivery directly to the brain for acute or chronic treatments. A direct route to the brain offers a rapid approach to delivering drugs to the central nervous system without using the parenteral route. Carmustine is a nitrosourea used to treat brain tumors, multiple myeloma, lymphoma, and Hodgkin’s disease but its use is limited by a very little half-life in the body fluids. The nanoparticles have shown great potential to overcome problems related to shorten shelf life. The present study aims to develop a nose-to-brain delivery system for Carmustine to prevent degradation and prolong it’s bioavailability at the target site. It has shown that the nanoparticles have uniform size and shape and were found to be 231±21.2 nm with 0.128 PDI. The system has stabilized with sufficient surface charge and the zeta potential of the system was found to be -21.2±2.3 mV. After 24 h, cumulative drug release from the prepared system was found to be the maximum release of around 96.69±3.38 in the phosphate buffer pH 6.8.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Potdar, M. B., Jain, N. K., Patil, K. D., & Goyal, Y. S. (2022). Development of Carmustine Loaded PLGA-PEG Conjugates for Nose to Brain Targeting. Indian Journal of Pharmaceutical Education and Research, 56(4), 1076-1082. https://doi.org/10.5530/ijper.56.4.188

    Copyright and licence

    © 2022 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0