Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity
1, 1, 1, 1, 1, 1, 1, 2
- 1College of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei, CHINA.
- 2Anhui Institute for Food and Drug Control, Hefei, CHINA.
CORRESPONDENCE
Prof. Hongmei Xia
Anhui University of Traditional Chinese Medicine, Longzihu Road, Hefei City, Anhui-230011, CHINA.
Received: 03-06-2022; Accepted: 11-10-2022.
Volume 57, Issue 1 · pp. 74-82 · 2023 · DOI: 10.5530/001954642087
ABSTRACT
Aim: Berberine hydrochloride is a Traditional Chinese Medicine component with antibacterial, antiviral, anti-inflammatory, antioxidant and lowering blood sugar effects. However, the application of berberine hydrochloride has been hindered for a long time due to its poor solubility and low bioavailability. This study aims to design a liposomes-gel to enhance the bioavailability and antioxidant activity of berberine hydrochloride.Materials and Methods: The thin-film dispersion hydration method was used to prepare liposomes, and liposomes-gel was prepared by the natural swelling method using sodium alginate as the hydrogel matrix. Berberine hydrochloride-loaded liposomes-gel was characterized by the encapsulation efficiency, particle size, potential, and transmission electron microscopy, and studied by in vitro release and antioxidant activity of the preparations.Results: The results revealed the encapsulation efficiency of berberine hydrochloride-loaded liposomes was 79.62±4.20% and the mean particle size was 153.7±11.2 nm. The release of berberine hydrochloride from liposomes-gel conformed to a first-order release model. The scavenging rate of DPPH free radicals and H2O2 by berberine hydrochloride-loaded liposomes-gel exceeds 70%.Conclusion: The liposomes-gel has a sustained-release effect on berberine hydrochloride. Berberine hydrochloride-loaded liposomes-gel had good antioxidant properties by measuring the scavenging ability on DPPH free radicals, H2O2 and lipid peroxidation resistance.
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Wang, M., Xia, H., Yang, X., Zhang, Q., Li, Y., Wang, Y., Xia, Y., & Xie, Z. (2023). Berberine Hydrochloride-loaded Liposomes Gel: Preparation, Characterization and Antioxidant Activity. Indian Journal of Pharmaceutical Education and Research, 57(1), 74-82. https://doi.org/10.5530/001954642087
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