Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis
1, 1, 1
- 1Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur, Maharashtra, INDIA.
CORRESPONDENCE
Dr. Mrs. Rita N. Wadetwar
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road, Nagpur-440 033, Maharashtra, INDIA.
Received: 27-10-2022; Accepted: 31-05-2023.
Volume 57, Issue 3s (Supplement) · pp. s573-s586 · 2023 · DOI: 10.5530/ijper.57.3s.66
ABSTRACT
Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated using Hydroxypropyl--cyclodextrin (HPCD). The complex was incorporated into mucoadhesive vaginal tablet using Chitosan and Hydroxypropyl Methyl Cellulose (HPMC K100).Materials and Methods: A 3^2 full factorial design was employed for sustained release tablet using Design expert software.Results: Scanning Electron Microscopy (SEM) results indicated the complex formation between the drug and HPCD. The batches showed 39.681.2 to 72.311.4% of drug release for 4 hr while for 8 hr it was from 77.231.5 to 99.821.1%. Therefore, the sustained release of drug was achieved for 8 hr. The tablet batches had swelling % from 228.5112 to 323.118% and mucoadhesive strength from 1131.0249 to 2302.1255 dyne/cm^2. In the in vitro antifungal activity study, a higher zone of inhibition was observed for the inclusion complex-based tablet (340.3 mm) as compared to plain drug tablet (250.4 mm).Conclusion: Therefore, the inclusion complex-based vaginal tablet could be formulated successfully by employing 3^2 full factorial design for increased residence of drug at the vaginal site of infection and for improved therapeutic efficacy.
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Kanojiya, P. S., Wadetwar, R. N., & Godbole, A. P. (2023). Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis. Indian Journal of Pharmaceutical Education and Research, 57(3s), s573-s586. https://doi.org/10.5530/ijper.57.3s.66
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