Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential
1, 1, 1
- 1Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
CORRESPONDENCE
Ms. Swetha Devidi
Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
Received: 25-09-2022; Accepted: 23-06-2023.
Volume 57, Issue 3s (Supplement) · pp. s742-s748 · 2023 · DOI: 10.5530/ijper.57.3s.84
ABSTRACT
Background: Design and development of target specific anti-cancer agents is a central research goal.Materials and Methods: Substituted pyrimidines were synthesized from substituted enamine, triethoxy methane and ammonium acetate. Characterization was done using IR, 1H-NMR, and mass spectra. Cytotoxicity was tested using MTT Assay on A 549, B16F10, SiHA, and MCF-7 cells.Results: Synthesized derivatives displayed noticeable cytotoxicity against tested cancer cell lines.Conclusion: Evaluated cell lines were susceptible to the novel pyrimidine derivatives, which may be transformed into potent anti-cancer leads.
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Devidi, S., Manickam, M. S., & Suresh, R. (2023). Multicomponent Synthesis, Characterization of Novel Pyrimidine Derivatives with Anti-cancer Potential. Indian Journal of Pharmaceutical Education and Research, 57(3s), s742-s748. https://doi.org/10.5530/ijper.57.3s.84
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This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0