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Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis

1, 1, 1, 2, 1, 1, 3

  1. 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.
  2. 2Department of Pharmaceutics, Jinnah University for Women, Karachi, PAKISTAN.
  3. 3Department of Chemistry, H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, PAKISTAN.

CORRESPONDENCE

Dr. Fatima Qamar

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jinnah University for Women, Karachi, PAKISTAN.

fatimamudassar2009@hotmail.com

Received: 25-01-2023; Accepted: 14-08-2023.

Volume 57, Issue 4 · pp. 1226-1231 · 2023 · DOI: 10.5530/ijper.57.4.146

ABSTRACT

Aim: Simple RP-HPLC method was developed and validated for the simultaneous estimation of Glimepiride, Glibenclamide and Moxifloxacin in pharmaceutical preparation.Materials and Methods: Mediterranean C18 column with dimensions of 150mm×4.6mm was used with HPLC Shimadzu LC-20 AT model, Version 1:62 is used for processing of chromatograms at room temperature (25± 2°C). 1 mL per minute was the flow rate and detector were set at 254nm with mobile Phase consisting of 85:10:5 v/v methanol: water: acetonitrile.Results: The developed method proved to be accurate, simple, effective precise and reproducible. One way ANOVA was also applied for further confirmation of the results.Conclusion: The method is applicable for the routine analysis of drugs in API and in formulation and for studying in vitro interaction studies.

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    Bashir, S., Qamar, F., Naveed, S., Zainab, S., Sadia, H., Sana, A., & Muzafar, W. (2023). Interaction Studies of Moxifloxacin with Anti-diabetic Drugs and Application of RP-HPLC in Analysis. Indian Journal of Pharmaceutical Education and Research, 57(4), 1226-1231. https://doi.org/10.5530/ijper.57.4.146

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    © 2023 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0