Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate
1, 1, 2
- 1Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
- 2Departmentof Pharmaceutics, Shri Ram Nath Singh Mahavidhalaya Pharmacy, Gormi, Bhind, Madhya Pradesh, INDIA.
CORRESPONDENCE
Varsha Bandil
Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
Received: 20-03-2023; Accepted: 08-08-2023.
Volume 58, Issue 1 · pp. 99-108 · 2024 · DOI: 10.5530/ijper.58.1.10
ABSTRACT
Background: The prime objective of our investigation was to optimize PLGA-chitosan nanoparticles containing vinorelbine ditartrate.Materials and Methods: The Vinorelbine ditartrate nanoparticles were formulated using emulsion method followed by probe sonication to reduce the size. A three factor three level Box-Behnken Design has been implemented to optimize chitosan, Poloxamer 188 and sonication time (independent variables) for particle size, polydispersity index and entrapment efficiency (%) as the measured responses. Particle size, zeta potential, surface morphology, entrapment effectiveness, and in vitro drug release were all evaluated for the optimised formulation.Results: The optimized PLGA-chitosan nanoparticle exhibited particles size of 161.22 nm with polydispersity index of 0.229 and zeta potential value of 10.99 mV. The formulation exhibited 78.9% entrapment of vinorelbine ditartrate. The nanoparticle was able to sustain the release of vinorelbine for more than 140 hr in the in vitro release studies.Conclusion: From studying the obtained results, it could be concluded from the investigation that PLGA-chitosan nanoparticles could be good approach to improve the bioavailability of the entrapped drug.
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Bandil, V., Gupta, J. K., & Goyal, M. K. (2024). Formulation, Optimization and Characterization of PLGA-Chitosan Nanoparticles Containing Vinorelbine Ditartrate. Indian Journal of Pharmaceutical Education and Research, 58(1), 99-108. https://doi.org/10.5530/ijper.58.1.10
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