Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Review

Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective

1, 1, 1, 1, 2, 2, 1, 1,5,6, 3, 4, 7, 1

  1. 1Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.
  2. 2Department of Pharmacology, BVDU’s Poona College of Pharmacy, Paudh Road, Erandawane, Pune, Maharashtra, INDIA.
  3. 3Department of Pharmaceutical Chemistry, UCPSc, Kakatiya University, Warangal, Telangana, INDIA.
  4. 4Department of Pharmaceutics, Sri Sanganabasava Mahaswamiji College of Pharmacy and Research Center, Vijayapura, Karnataka, INDIA.
  5. 5Department of Entomology, University of California, Davis, One Shields Ave, Davis, CA, USA.
  6. 6UC Davis Comprehensive Cancer Centre, University of California, Davis, One Shields Ave, Davis, CA, USA.
  7. 7Department of Pharmacognosy, BVDU’s Poona College of Pharmacy, Paud Road, Erandawane, Pune, Maharashtra, INDIA.

CORRESPONDENCE

Ravindra Kulkarni

Department of Pharmaceutical Chemistry, BVDU’S Poona College of Pharmacy, Erandwane Pune, Maharashtra, INDIA.

ravigk2000@gmail.com

Received: 25-01-2023; Accepted: 03-11-2023.

Volume 58, Issue 1s (Supplement) · pp. s58-s66 · 2024 · DOI: 10.5530/ijper.58.1s.5

ABSTRACT

Tuberculosis is a pathogenic infection that has created trepidation around the globe due to its repercussion on the health of patients. The iron transport mechanism in mycobacterium plays a pivotal role in bacterial survival; whilst this can be considered an emerging drug target. Salicylate synthase is a member of the MST family and this enzyme is distrait in mammals. It is the first enzyme for the synthesis of mycobactin (siderophores) which is a determinant for iron transport. The present all-embracing review provides overall coverage of the biological and structural outlook of the enzyme salicylate synthase and its inhibitors reported in recent years. Furthermore, this review sheds limelight on the development of novel and more potent salicylate synthase inhibitors.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Bire, N., Walhekar, V., Makane, O., Yelchatwar, P., Muthal, A., Bodhankar, S., Bagul, C., Kumar, D., Macha, B., Kulkarni, R., Shinde, V., & Kulkarni, R. (2024). Molecular Insights into Salicylate Synthase: From Medicinal Chemistry Perspective. Indian Journal of Pharmaceutical Education and Research, 58(1s), s58-s66. https://doi.org/10.5530/ijper.58.1s.5

    Copyright and licence

    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0