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Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
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Effectiveness of Complementary and Alternative Medicine and Physical Therapies in Peripheral Arterial Disease with Intermittent Claudication: A Systematic Review

1, 2, 3, 3, 4, 5, 3, 6, 7, 8, 9, 10, 10

  1. 1Department of Clinical Pharmacy, King Fahad Medical City, Riyadh, SAUDI ARABIA.
  2. 2Department of Cardiac Science, College of Medicine, King Saud University, Riyadh, SAUDI ARABIA.
  3. 3Department of Pharmacy, Maternity and Children Hospital Rafah, Rafha, SAUDI ARABIA.
  4. 4Department of Clinical Pharmacy, Western Zone, Taif, SAUDI ARABIA.
  5. 5Department of Community Pharmacy, Kol Alosra, Western Zone, Taif, SAUDI ARABIA.
  6. 6Department of Pharmacy, Prince Sultan Cardiac Center, Riyadh, SAUDI ARABIA.
  7. 7College of Pharmacy, Northern Border University, Hafar Al-Batin, SAUDI ARABIA.
  8. 8College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, SAUDI ARABIA.
  9. 9College of Pharmacy, Northern Border University, Rafha, SAUDI ARABIA
  10. 10College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.

CORRESPONDENCE

Dr. Mohammed Kanan Alshammari

Department of Clinical Pharmacy, King Fahad Medical City, Riyadh-12211, SAUDI ARABIA.

ii_kanan101@outlook.com

Received: 03-07-2023; Accepted: 19-01-2024.

Volume 58, Issue 2s (Supplement) · pp. s340-s353 · 2024 · DOI: 10.5530/ijper.58.2s.37

ABSTRACT

Aim/Background: Peripheral Arterial Disease (PAD) affects the lower limbs. Globally there is a growing disease burden among the patients suffering from cardio-vascular disease and metabolic disorders. The purpose of this review is to generate evidence on the efficacy of CAM therapies in PAD.Materials and Methods: This systematic review was performed across the five electronic databases i.e. PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Ovid SP, ISI Web of Science, Elsevier Science Direct, and Wiley Online Library as per the PRISMA guidelines from inception till April 2022.Results: After screening n=55,410 articles, n=77 articles were found to fulfill the eligibility criteria and were selected for this review. The nature of interventions investigated in the clinical trials were physical interventions including exercises of different forms, oral supplements, and other interventions such as chelation therapy, Tai Chi Chuan (TCC), Intermittent Mechanical Compression (IMC) device, connective tissue reflex massage, Remote Ischemic Preconditioning (RIC), Transcutaneous Electrical Nerve Stimulation (TENS) and heat therapy. Upon final assessment, it was revealed that physical activity had a positive effect on peripheral arterial disease patients’ quality of life. In addition,Ginkgo biloba and nitrate supplements were found effective for Intermittent Claudication (IC) and PAD patients.Conclusion: This review suggests a positive impact of physical activity on peripheral arterial disease patients’ quality of life. Evidence also shows that Physical activity/ exercise-based intervention alone or in combination with the supplement is found to be effective among PAD patients and has shown significant results in intermittent claudication.

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    Alshammari, M. K., Hussain, K. H., Alshammari, M. R., Alshammari, H. H., Althagafi, H. S., Bajunaid, H. R., Alanzi, B. A., Alshammari, A. A., Alshammari, A. K., Aljasim, M. A. J., Alanizi, Y. S., Al-Sulais, W. M., & Albaqami, A. A. A. N. D. (2024). Effectiveness of Complementary and Alternative Medicine and Physical Therapies in Peripheral Arterial Disease with Intermittent Claudication: A Systematic Review. Indian Journal of Pharmaceutical Education and Research, 58(2s), s340-s353. https://doi.org/10.5530/ijper.58.2s.37

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    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0