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QBD-Powered Design and Optimization of Nanostructured Lipid Carriers Loaded with BCS class IV Anticancer Drug

1, 1, 2, 3

  1. 1Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.
  2. 2Department of Pharmaceutics, St. Pauls College of Pharmacy, Turkyamjal, Hyderabad, Telangana, INDIA.
  3. 3Department of Pharmaceutical Analysis, St. Pauls College of Pharmacy, Turkyamjal, Hyderabad, INDIA.

CORRESPONDENCE

Mrs. P. Naga Haritha

Department of Pharmacy, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, INDIA.

harithasunilp.hs@gmail.com

Received: 30-03-2023; Accepted: 13-05-2024.

Volume 58, Issue 3s (Supplement) · pp. s828-s836 · 2024 · DOI: 10.5530/ijper.58.3s.84

ABSTRACT

Background: The therapeutic efficacy of an active Pharmaceutical ingredient depends on its solubility in body fluids. The low bioavailability of nearly 90% of new active Pharmaceutical ingredients and 40% of the existing molecules is attributed to their poor solubility. The current study aimed to improve the oral bioavailability of lapatinib by designing and optimizing nanostructured lipid carriers for it.Materials and Methods: The formulation utilized the microemulsion technique as a method of preparation and the Box Behnken design was used for optimization.Results: The average particle size, drug entrapment, and release, in percentages, were observed to be 237.09 nm, 72.32%, and 74.66% respectively.Conclusion: In vitro studies proved that NSLC significantly releases a drug more than the marketed formulation.

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    Haritha, P. N., Janakiraman, K., Madhav, K. V., & Chaitanya, P. S. K. (2024). QBD-Powered Design and Optimization of Nanostructured Lipid Carriers Loaded with BCS class IV Anticancer Drug. Indian Journal of Pharmaceutical Education and Research, 58(3s), s828-s836. https://doi.org/10.5530/ijper.58.3s.84

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    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0