Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Optimization and Characterization of Lamivudine-Loaded TCS-PEG/MMT Polymeric Nanocomposites for Enhanced Antiretroviral Therapy

1, 2, 2, 3, 3, 3, 4,5, 1, 6, 7

  1. 1Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  2. 2Department of Pharmaceutics, SJM College of Pharmacy, Chitradurga, Karnataka, INDIA.
  3. 3Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar, Karnataka, INDIA.
  4. 4Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Hofuf, Al-Ahsa, SAUDI ARABIA.
  5. 5Department of Pharmaceutics, Vidya Siri College of Pharmacy, Off Sarjapura Road, Bangalore, Karnataka, INDIA.
  6. 6Department of Pharmacy Practice, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
  7. 7Department of Medicine, College of Medicine, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.

CORRESPONDENCE

Dr. N. Raghavendra Naveen

Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G. Nagar-571448, Karnataka, INDIA.

nrn@accp.co.in

Received: 03-01-2024; Accepted: 04-05-2024.

Volume 58, Issue 3s (Supplement) · pp. s910-s924 · 2024 · DOI: 10.5530/ijper.58.3s.92

ABSTRACT

Background: Acquired Immunodeficiency Syndrome (AIDS), caused by the Human Immunodeficiency Virus (HIV) was initially associated with rapid disease progression and high mortality rates. However, advances in drug delivery systems have aimed to optimize therapeutic outcomes, especially for medications facing challenges such as toxicity, uneven distribution, instability and formulation complexities.Materials and Methods: In this study, we introduce TCS-PEG/MMT composites, a novel formulation designed for antiretroviral activity. This formulation consists of a blend of Medical clay (MMT) and Thiolated Chitosan and Polyethylene Glycol (TCS-PEG), which are biodegradable materials. Using Design Expert software, we optimized the loading procedure of lamivudine onto chitosan (X1), MMT (X2) and PEG (X3) to achieve desired Entrapment Efficacy (EE) and particle size (PS). The desirability technique helped determine an optimal formulation with 3 g of chitosan, 3 g of MMT and 2.5 g of PEG.Results: The optimized formulation exhibited an EE of 79.58% and a PS of 592.32 nm. We conducted comprehensive analyses on the Optimized formulation (O-LMD-NC), including assessments of swelling characteristics, surface morphology, drug loading, entrapment efficiency and particle size. Water absorption of O-LMD-NC samples gradually increased over time, reaching a maximum of 13.5 g/g after 24 hr. In vitro drug release studies confirmed sustained release of lamivudine over a 24 hr period.Conclusion: Our findings suggest that LMD-loaded polymeric nanocomposites offer a promising approach to enhance the efficacy of AIDS treatment.

KEYWORDS

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Meravanige, G., Gajula, L. R., Rangappa, A. B., Goudanavar, P., Sridhar, S. K., Naveen, N. R., Sreeharsha, N., Shiroorkar, P. N., Asif, A. H., & Telsang, M. (2024). Optimization and Characterization of Lamivudine-Loaded TCS-PEG/MMT Polymeric Nanocomposites for Enhanced Antiretroviral Therapy. Indian Journal of Pharmaceutical Education and Research, 58(3s), s910-s924. https://doi.org/10.5530/ijper.58.3s.92

    Copyright and licence

    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0