Metal Complexes of Curcumin: A Comprehensive Approach to Design, Synthesis, Characterization and Assessment of Anti-tubercular Activity
1, 1, 1, 2
- 1Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Chikkabellanduru, Carmelaram Post, Varthur, Bangalore, Karnataka, INDIA.
- 2Principal, Krupanidhi College of Pharmacy, Bangalore, Karnataka, INDIA.
CORRESPONDENCE
Dr. Paramita Das
Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, #12/1 Chikkabellanduru, Carmelaram Post, Varthur, Bangalore-560035, Karnataka, INDIA.
Received: 07-02-2024; Accepted: 20-04-2024.
Volume 58, Issue 3s (Supplement) · pp. s963-s972 · 2024 · DOI: 10.5530/ijper.58.3s.96
ABSTRACT
Background: The primary challenge facing Tuberculosis (TB) is the growing prevalence of drug resistance and the hepatotoxicity secondary effects of first and second-line anti-TB treatments have reignited interest in exploring new metal drug complexes as possible sources of anti-TB medications.Aim: To perform in silico studies for Curcumin-metal complexes, synthesis and evaluate their antitubercular activity and cytotoxicity.Materials and Methods: Designed metal complexes were docked against 2NSD and performed ADMET studies. Based on binding affinity, a series of Curcumin-metal complexes were synthesized, characterized by IR, NMR, MASS, P-XRD and the antitubercular activity was evaluated by MABA and MTT assay for cytotoxicity investigations. Results and Discussion: The binding energies ranged from -8.0 to -10.1 ‘kcal/mol’. At -10.1 ‘kcal/ mol’, the Curcumin-Cu complex (C1) exhibited the best binding. The synthesized compounds was evaluated against Mycobacterium tuberculosis (H37Rv) using the MABA assay. Curcumin-Cu complex (C1) showed the highest activity and was the most sensitive at 0.8 μg/mL and showed less toxicity with an IC50 of 10.0 and a selectivity index of 4.0. Cytotoxicity was evaluated by the ATCC CCL-81 cell line.Conclusion: Therefore, we can conclude that the molecular hit will be a good lead to develop novel therapies for tuberculosis treatment.
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Das, P., Yamuna, H., Harshashree, M., & Dang, R. (2024). Metal Complexes of Curcumin: A Comprehensive Approach to Design, Synthesis, Characterization and Assessment of Anti-tubercular Activity. Indian Journal of Pharmaceutical Education and Research, 58(3s), s963-s972. https://doi.org/10.5530/ijper.58.3s.96
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