Bioactivities, Biopharmaceutics, and Advanced Drug Delivery Systems of Magnolol
1,2, 1, 1, 1,2, 1,2, 3
- 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA.
- 2Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, SAUDI ARABIA.
- 3Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, SAUDI ARABIA.
CORRESPONDENCE
Sabna Kotta
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, SAUDI ARABIA.
Received: 28-08-2024; Accepted: 25-10-2024.
Volume 58, Issue 4s (Supplement) · pp. s1108-s1127 · 2024 · DOI: 10.5530/ijper.58.4s.110
ABSTRACT
Magnolia bark is an important food supplement. Magnolol (ML), 3,3′-Neoligna-8,8′-diene-4,4′- diol, is a bioactive phenolic molecule found in the Magnolia family. Advanced Drug Delivery Systems (DDSs) have been able to enhance therapeutic efficacy and reduce adverse effects of plant-derived bioactive. In the first part of the review, the bioactivities, mechanisms, and clinical prospects of ML are described. A brief explanation of the mechanisms of anti-inflammatory, antioxidant, cardiovascular-protective, neuroprotective, and anti-cancer effects of ML is also provided. Later, the detailed biopharmaceutics of ML is described under solubility, dissolution, bioavailability, and pharmacokinetics. The solubility of ML in different media pH is also explained. The bioavailability of pure ML and its pharmacokinetics after parenteral and oral administrations are described. Further, pharmacokinetics after single and multiple doses of ML is also discussed. Finally, the reported advanced DDSs of ML are reviewed critically. Engineered crystals, solid dispersions, microstructures, and nanostructures of ML-loaded DDSs are reviewed.
KEYWORDS
REFERENCES
As publishedShowing references and in-text citations exactly as published.
Cite this article
SELECT FORMAT
Kotta, S., Eshmawi, B. A., Alahmadi, A. A., Aldawsari, H. M., Badr-Eldin, S. M., & Nair, A. B. (2024). Bioactivities, Biopharmaceutics, and Advanced Drug Delivery Systems of Magnolol. Indian Journal of Pharmaceutical Education and Research, 58(4s), s1108-s1127. https://doi.org/10.5530/ijper.58.4s.110
Copyright and licence
© 2024 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0