An Insight into the Synthetic Strategies and Pharmacological Effects of Cinnoline Derivatives

Abstract

Background: The cinnoline ring is a new aromatic heterocyclic connected with two nitrogen atoms in a 6 membered ring and compounds containing this ring have been shown to have a wide variety of pharmacologicaleffects.Objectives: This review studyextensively explains the synthetic strategy by which researchers have produced cinnoline derivatives reported to have numerous pharmacological effects, including antitubercular, antibacterial, anticancer, antimolluscidal, etc.Materials and Methods: The cinnoline moiety is a highly powerful lead that may give a range of pharmacological effects and this study provides brief information on the various synthesis techniques and pharmacological activity of reported cinnoline analogs that support this claim.Results: This succinct review summarizes the several known cinnoline analogs, outlining their respective synthesis strategies and pharmacological activity and conclusively showing that the cinnoline moiety is a potent lead capable of producing a wide range of therapeutic actions.Conclusion: This article’s literature review will serve as a springboard for further research into the synthesis of cinnoline derivatives, which in turn will aid in the creation of cinnoline-based compounds with improved pharmacokinetic and pharmacodynamic characteristics.

Keywords: Cinnoline; Aromatic; Synthesis; Pharmacokinetic; Heterocyclic; Pharmacological effects