Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia

1, 1, 1,2,3, 1, 1, 1,3, 4, 3,5, 6, 1, 7

  1. 1Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
  2. 2Substance Abuse and Toxicology Research Centre, Jazan University, Jazan, SAUDI ARABIA
  3. 3Health Research Center, Jazan University, Jazan, SAUDI ARABIA
  4. 4Unit of Medical Microbiology, College of Applied Medical Sciences, Jazan University, Jazan, SAUDI ARABIA
  5. 5Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
  6. 6Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, SAUDI ARABIA
  7. 7Department of Pharmacology, Dr. Joseph Mar Thoma Institute of Pharmaceutical Sciences and Research, Kattanam, Alappuzha, Kerala, INDIA

CORRESPONDENCE

Dr. Md Shamsher Alam

Department of Pharmaceutical Chemistry and Pharmacognosy, College of Pharmacy, Jazan University, Jazan-45142, SAUDI ARABIA.

mosalam@jazanu.edu.sa

Received: 28-08-2024; Revised: 12-09-2024; Accepted: 04-10-2024.

Volume 59, Issue 1 · pp. 175-184 · 2025 · DOI: 10.5530/ijper.20250719

ABSTRACT

Background: This study evaluated the chemical composition, antioxidant activity and antibacterial properties of methanol extracts of Ocimum basilicum L. leaves that were gathered from the Kingdom of Saudi Arabia's Jazan province.Materials and Methods: The extract was examined using FTIR and GC-MS techniques, which revealed the presence of terpenes (53.14%), Linalool (24.5%), sulfoxides (4.19%), cinnamic acid (5.23%), fatty acid esters (1.45%) and phthalic acid esters (0.72%).Results: The extract contained significant levels of total phenolic compounds and demonstrated a DPPH radical scavenging capacity of 33.70%, which is considered to be good. The antibacterial activity spectrum of O. basilicum leaves' methanolic extract was found to be broader. The extract was tested against eight different bacteria strains, including S. cholestasis, S. aureus, S. epidermidis, K. pneumoniae, E. coli, P. mirabilis, E. faecalis, and S. cholestasis.Conclusion: With an inhibition zone of 21 mm, S. aureus exhibited the highest level of antibacterial activity, whereas P. aeruginosa demonstrated the lowest value, with an inhibition zone of 15 mm. Nonetheless, the activity range was more constrained than that of regular ciprofloxacin discs.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Alam, M. S., Albratty, M., Ahmed, H. A. H., Najmi, A., Zoghebi, K., Rehman, Z. U., Basode, V. K., Moni, S. S., Alam, M. F., Ahsan, W., & Kochikuzhyil, B. M. (2025). Spectral Characterization, Antioxidant and Antibacterial Activities of Cold Methanolic Extract of Sweet Basil (Ocimum basilicum L.) Leaves Growing in Jazan, Kingdom of Saudi Arabia. Indian Journal of Pharmaceutical Education and Research, 59(1), 175-184. https://doi.org/10.5530/ijper.20250719

    Copyright and licence

    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0