Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi
1, 2, 1, 3, 3, 4, 5
- 1Department of Microbiology, Muthayammal College of Arts and Science, Rasipuram, Tamil Nadu, INDIA
- 2Department of Education, The Gandhigram Rural Institute, Gandhigram, Dindigul, Tamil Nadu, INDIA
- 3Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, SAUDI ARABIA
- 4Department of Chemistry, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, INDIA
- 5Centre for Integrative Medical Research, Sree Balaji Medical College and Hospital (SBMCH), Chromepet, Chennai, INDIA
CORRESPONDENCE
Dr. Natesan Sudhakar
Department of Microbiology, Muthayammal College of Arts and Science, Namakkal-637408, Tamil Nadu, INDIA.
Received: 07-07-2024; Revised: 12-08-2024; Accepted: 18-11-2024.
Volume 59, Issue 1 · pp. 230-241 · 2025 · DOI: 10.5530/ijper.20250286
ABSTRACT
Background: Trachyspermum ammi (T. ammi) holds a longstanding position in traditional medicinal practices, renowned for its diverse medicinal and pharmacological attributes. Medicinal plants not only offer significant therapeutic benefits but also hold economic importance. A noteworthy trait of phytomedicine lies in its low toxicity, which positively impacts the pharmaceutical market. Hence, traditional practices often incorporate detoxification/purification methods to mitigate the toxicity of herbs.Objectives: Aimed at scientifically validating these practices, our study explores the traditional detoxification method known as Sodhana and assessing its Influence on T. ammi.Materials and Methods: We evaluate the antimicrobial, phytochemical, heavy metal content and anti-inflammatory efficacy of detoxified T. ammi seeds.Results: The seeds undergo lime treatment, followed by grinding into powder and extraction with 90% ethanol. Our antimicrobial study reveals that lime-treated ethanol extract exhibits robust inhibitory activity against various microbial strains, surpassing the unprocessed extract in most cases. Notably, significant reductions in heavy metal content are observed post-lime treatment, particularly in titanium, indium, bismuth, strontium, lead, aluminum, boron, mercury, and cadmium. Phytochemical analyses via ICP/OES, GC-MS and LC-MS demonstrate alterations in compound compositions between unprocessed and lime-treated extracts, with the latter exhibiting elevated levels of thymol and fatty acids. Furthermore, our investigation highlights the considerable anti-inflammatory potential of lime-treated T. ammi seed extracts.Conclusion: In conclusion, our findings emphasize the efficacy of lime treatment in reducing toxic elements while enhancing antimicrobial and anti-inflammatory properties, thus advocating for its utilization in traditional herbal practices.
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Vanitha, K. G., Natarajan, N. A., Sudhakar, N., Hirad, A. H., Alarfaj, A. A., Arulselvan, P., & Raja, R. (2025). Enhancing Therapeutic Potential: Investigating Traditional Detoxification Methods and Assessing their Influence on Anti-Microbial Efficacy, Phytochemical Composition, Heavy Metal Content and Anti-inflammatory Properties in Trachyspermum ammi. Indian Journal of Pharmaceutical Education and Research, 59(1), 230-241. https://doi.org/10.5530/ijper.20250286
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