Bio-Conjugated Metallic Complexes in Drug Design

Abstract

Background: This comprehensive review highlights the importance of bio-conjugated metallic complexes in drug design, particularly in the field of metallo-pharmaceutical science. The review emphasizes the need for biological relevance and the coordination of biomolecules or modified bio-compounds with metallic systems to maximize drug action and minimize toxicity.Materials and Methods: The objective of this review is to discuss various diseases, which exemplify the potential of bio-conjugated metallic complexes as a promising approach for drug design.Results: Utilizing physiologically active ligands in metal complexes has demonstrated improved antioxidant, antiviral, antitubercular and antitumor effects.Conclusion: Bio conjugated systems have become a viable method for creating molecules with several uses that are good for human health. The development of metal-based imaging agents and drug delivery systems has increased due to the conjugation of metals with biologically active compounds.

Keywords: Bio-conjugation; Metallic complexes; Drug design; Metallo-pharmaceutical science; Antioxidants; Chelate