Role of Brain Ang (1-7) With Combination Therapy of Aliskerin in Control of Diabetic Nephropathy
1, 1, 2
- 1Department of Pharmacology, Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, INDIA.
- 2Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, INDIA.
CORRESPONDENCE
Ms. Richa Shakya
Department of Pharmacology Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, INDIA.
Received: 11-12-2023; Revised: 17-05-2024; Accepted: 23-12-2024.
Volume 59, Issue 2s (Supplement) · pp. s633-s640 · 2025 · DOI: 10.5530/ijper.20255883
ABSTRACT
Objectives: Angiotensin (1-7) system has been recognizing as physiologically major content of the renin-angiotensin system. It exhibited that Diabetic Nephropathy (DN), which is prevalent causes of end-stage renal disease, reduces Ang (1-7) peripheral activity. RAS activity in the PNS is controlled by RAS in the brain. The goal of this research is to see whether cerebral angiotensin (1-7) has a role in chronic diabetic kidney disease in wistar rats.Materials and Methods: Single dosage of streptozotocin 35 mg/kg i.p causes Diabetes Mellitus (DM). 2 doses of aliskerin and Ang (1-7) via a various route. After that there were testing of the samples. Commercially available kits were used to determine biochemical parameters linked to DN.Results: When streptozotocin was given to diabetic rats for 10 weeks, the mice displayed higher serum creatinine, blood urea as well as protein in urine, as well as a decreased amount of serum nitrite. A 2-week course of intracerebral aliskerin (100 nmol/day) and Ang (1-7) treatment decreased such changes also elevated serum nitrite in rats with DN, but only in conjunction with Ang (1-7) (4.8 g/day) separately or in combinations.Conclusion: The findings of current research imply that brain Ang (1-7) is vital in RAS peripheral activity modulation in diabetic nephropathy, which might be attributed to Ang II peripheral activity and reduced central sympathetic outflow.
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Shakya, R., Gupta, J. K., & Mazumder, A. (2025). Role of Brain Ang (1-7) With Combination Therapy of Aliskerin in Control of Diabetic Nephropathy. Indian Journal of Pharmaceutical Education and Research, 59(2s), s633-s640. https://doi.org/10.5530/ijper.20255883
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