Indian Journal of Pharmaceutical Education and Research logo
Submit
Indian Journal of Pharmaceutical Education and ResearchAn Official Publication of Association of Pharmaceutical Teachers of India (APTI)
Article

Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats

1, 2, 4

  1. 1Medical Faculty, Masters Program in Biomedical Sciences, Universitas Methodist Indonesia, INDONESIA, INDONESIA.
  2. 2Department of Physiology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.
  3. 3Department of Molecular Biology, Masters Program in Biomedical Sciences, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.
  4. 4Department of Parasitology and Immunology, Faculty of Medicine, Universitas Methodist Indonesia, Medan, INDONESIA.

CORRESPONDENCE

Ade Dwi PratiwiMedical

Faculty, Masters Program in Biomedical Sciences, Universitas Methodist Indonesia, INDONESIA.

Adedwipratiwi90@gmail.com

Received: 15-11-2024; Revised: 02-01-2025; Accepted: 28-04-2025.

Volume 59, Issue 3s (Supplement) · pp. s921-s929 · 2025 · DOI: 10.5530/ijper.20250752

ABSTRACT

Background: This study investigated the effect of rosella flower petal (Hibiscus sabdariffa L.) ethanol extract gel on incision wound healing in a rat model of diabetes mellitus. Wounds are skin disorders that can be caused by internal or external factors. The wound healing process involves various growth factors, including Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1).Materials and Methods: This study used a post-test-only controlled group design with male Wistar rats as the research subjects. This study aimed to evaluate the effect of rosella flower petal ethanol extract gel on FGF-2 and MMP-1 levels, as well as collagen and fibroblast cell formation in the wound healing process.Results: Phytochemical screening results revealed the presence of flavonoids, alkaloids, saponins, phenols, and tannins in rosella extract. The results showed a significant difference (p<0.05) in FGF-2 levels between all research groups and significant difference (p<0.05) in MMP-1 levels.Conclusion: The group that received ethanol extract gel of rosella flower petals with a concentration of 12% showed a better increase in the formation of FGF-2, MMP-1, collagen, and fibroblast cells compared to the other groups

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Pratiwi, A. D., Siahaan, J. M., & Anto, E. J. (2025). Effect of Ethanol Extract of Rosella Flower (Hibiscus sab- dariffa L.) on the Expression of Fibroblast Growth Factor-2 (FGF-2) and Matrix Metalloproteinase-1 (MMP-1) in the Healing Process of Incision Wounds in White Wistar Rats. Indian Journal of Pharmaceutical Education and Research, 59(3s), s921-s929. https://doi.org/10.5530/ijper.20250752

    Copyright and licence

    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. CC BY 4.0